Reproductive System and Pregnancy

Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination

The paper finds that early pregnancy SARS2 vaccination is associated with increased detection of T cell maternal microchimerism in cord blood.

A stress-responsive morphogenetic program coordinates uterine luminal remodeling during early pregnancy

The paper identifies a stress-responsive morphogenetic program in the uterus that coordinates luminal remodeling during early pregnancy, essential for successful embryo implantation.

A 3D in vitro follicle-endometrial organoid co-culture model recapitulates ovarian control of human endometrial decidualization

This paper develops a 3D in vitro model of ovarian follicle-endometrial organoid co-culture that mimics ovarian control of endometrial decidualization, showing similar but distinct transcriptional patterns compared to traditional hormone-based methods.

Dynamic Changes in Endometrial Folding and Secretory Activity Across the Menstrual Cycle

The paper examines endometrial folding and secretory activity during the menstrual cycle to identify markers of endometrial receptivity.

Maternal immune gene expression trajectories and dynamic genetic regulation throughout pregnancy

This study tracks maternal immune gene expression and genetic regulation throughout pregnancy, revealing dynamic changes and genetic interactions linked to pregnancy complications.

Cell-type-specific expression of classical and membrane progesterone receptors at the human maternal-fetal interface

The paper identifies cell-type-specific expression patterns of classical and membrane progesterone receptors at the human maternal-fetal interface using single-cell and spatial transcriptomic data.

Machine learning-driven decoding of maternal immune signatures in repeated pregnancy loss

The paper identifies maternal immune signatures in repeated pregnancy loss using single-cell RNA sequencing and machine learning, linking them to potential drug repurposing candidates.

ERBB2 establishes the timing of progesterone priming required for uterine receptivity

This study shows ERBB2 controls the timing of progesterone responsiveness in the uterus, ensuring proper receptivity for implantation.

Spatial Logic and Evolutionary Innovation in Human Placentation

The paper uses single-nucleus RNA-seq and spatial transcriptomics to show how the maternal-fetal interface diverges in structure and function between the basal plate and chorionic membranes, identifying NID2 as an ancestry-associated regulator of trophoblast invasion.

Luminal epithelium remodeling underlies endometrial regeneration during menstruation and pregnancy

This study shows that luminal epithelium, not glandular cells, drives endometrial regeneration during menstruation and pregnancy in mice, revealing a unifying mechanism for tissue repair.

A 28-color panel for classical and non-classical T lymphocytes in decidua and PBMC in rhesus macaques

This paper develops a 28-color flow cytometry panel to identify T lymphocytes, B cells, and NK cells in rhesus macaque decidual and PBMC samples, enabling analysis of maternal immune responses during pregnancy.

Transcriptomic Analysis Reveals Inflammatory and Metabolic Dysregulation in Unexplained Female Infertility

This study identifies 168 differentially expressed genes in endometrial tissue from unexplained female infertility using transcriptomic analysis and finds associations with immune-inflammatory pathways and lipid metabolism.

Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation

This study shows that type V collagen is essential for decidual ECM organization and angiogenesis during embryo implantation, with its absence causing pregnancy loss.

Endometrial transcriptomic and ciliation analysis after scratch shows no signature linked to live birth following IVF

This study analyzes endometrial transcriptomic and ciliation changes after IVF scratch, finding no association with live birth outcomes.

Arginine methyltransferase PRMT1 equipoises trophoblast development to prevent early pregnancy loss

This study identifies PRMT1 as a critical regulator of trophoblast development, showing its role in preventing early pregnancy loss through epigenetic control of stemness and differentiation.

Modeling human embryo adhesion using a microfluidic platform

This paper presents a microfluidic platform to model human embryo adhesion and endometrial interactions, showing embryo-epithelial contacts and hormone-induced receptivity.

TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

This study shows that TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells during murine pregnancy, supporting reproductive success.

Natural killers in pregnancy: servants of two masters

This paper proposes a hypothesis that random KIR gene expression and two-way tuning of dNK cells influence placental development and pregnancy outcomes, without specific HLA/KIR genotypes causing recurrent pregnancy loss.

Trophoblast stem cells and syncytiotrophoblasts lack inflammatory responses to LPS but retain robust interferon-mediated antiviral immunity

This study shows trophoblast stem cells and syncytiotrophoblasts do not respond to LPS but have strong interferon-mediated antiviral responses, suggesting maternal immune activation, not microbial invasion, drives early placental immunity.

Aberrations in stromal signaling, muscle contractility and epithelial architecture underlie poor embryo-implantation outcomes after murine ovarian stimulation

This study shows that ovarian stimulation disrupts uterine structure and function in mice, leading to poor embryo implantation, and identifies PDGFRA signaling as a key factor.

Human tissue-resident CD8 T cells contribute to trophoblast homeostasis in health and during acute inflammation

The paper examines how T cell-tissue cell communication changes in human placental tissue during acute inflammation, finding that tissue-resident CD8 T cells support trophoblast homeostasis in both healthy and inflamed states.

Loss of Glucose Transporter 1 in Mouse Uterine Cells Disrupts Trophoblast Differentiation and Promotes Gestational Diabetes

This study shows that loss of Glut1 in mouse uterine cells disrupts trophoblast differentiation and causes gestational diabetes.

Distinct immune responses to HIV and CMV in Hofbauer cells across gestation highlight evolving placental immune dynamics

This study examines how Hofbauer cells respond to HIV and CMV at different gestational stages, revealing distinct transcriptional and functional immune responses that evolve during pregnancy.

EndoTwin-W: glycodelin-A and CA-125 as non-invasive biomarkers of endometrial receptivity derived from a multiscale computational digital twin

EndoTwin-W is a computational model that identifies glycodelin-A and CA-125 as non-invasive biomarkers for endometrial receptivity, validated across multiple datasets and showing significant correlation with tissue data.

Hormonal stimulation induces broader decidualization responses than cAMP alone in 3D human endometrial organoids

This study compares cAMP and EPC-induced decidualization in 3D human endometrial organoids, finding that EPC induces broader and more physiologically relevant transcriptional changes.

Whole slide image analysis of the endometrial decidual reaction reveals multiscale perturbations associated with miscarriage

The paper develops a deep learning tool to analyze endometrial histology and identifies morphological correlates of miscarriage risk.

Steroid Hormone-Induced LIF Regulates Vasoactive Mediators During Implantation and Decidualization in the Golden Hamster

This study investigates the regulation of LIF by uterine factors and estrogen in golden hamster during early pregnancy, showing LIF upregulation around implantation and its role in activating prostaglandin enzymes for successful pregnancy.

High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third trimester pregnancy

This study identifies changes in CD4+ T cell surface proteins and transcriptomes during pregnancy, highlighting perturbations in the IL-6/IL-6R axis and RUNX3 expression.

Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells

This study identifies functional differences in term decidual natural killer cells compared to early gestation and develops a protocol to generate functional early gestation-like dNK from iPSC.

Regional epithelial architecture and spatial distribution of T and B lymphocytes in the human fallopian tube

The paper examines the epithelial architecture and spatial distribution of T and B lymphocytes in different regions of the human fallopian tube across the menstrual cycle.