Reproductive System and Pregnancy

Early infection response of the first trimester human placenta at single-cell scale

This study uses single-cell transcriptomics to map the early placental response to three pathogens in first-trimester human placenta, identifying coordinated inflammatory responses and pathogen-specific effects.

Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage

This study conducts a trans-ancestral GWAS of sporadic and recurrent miscarriage, identifying novel genetic associations and providing causal evidence for smoking and caffeine consumption.

Successful placentation in human pregnancy is regulated by reciprocal interactions between maternal uterine NK cells and fetal placental trophoblast

The paper identifies a uNK-derived cytokine signal that promotes trophoblast differentiation and influences placental function and pregnancy outcomes.

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

The paper uses affinity-tagged SMAD1 and SMAD5 mouse lines to study their roles in endometrial decidualization during early pregnancy, revealing their genomic binding patterns and functional impact on decidual marker expression.

Targeted gene expression profiling for accurate endometrial receptivity testing

The paper develops a targeted gene expression assay to assess endometrial receptivity, finding higher rates of shifted window of implantation in recurrent implantation failure patients.

Fibroblast activation during decidualization: Embryo-derived TNFα induction of PGI2-PPARδ-ACTIVIN A pathway through luminal epithelium

This study identifies a pathway by which embryo-derived TNFα induces fibroblast activation and decidualization through the arachidonic acid-PGI2-PPARδ-ACTIVIN A axis in mouse and human endometrium.

lincRNA RP24-315D19.10 promotes endometrialdecidualization via upregulation of hnRNPA2B1

The paper identifies lincRNA RP24-315D19.10 as a promoter of endometrial decidualization by upregulating hnRNPA2B1 in mouse cells and links its dysregulation to spontaneous miscarriage.

Melatonin alleviates LPS-induced abnormal pregnancy through MTNR1B regulation of m6A

This study shows melatonin protects pregnancy by regulating m6A through MTNR1B, reducing inflammation and cell death in response to LPS.

Baicalin Ameliorates Defective Decidualization in URSA by Regulating Mitochondrial Fission Induced Necroptosis

This study investigates how baicalin improves defective decidualization in URSA by reducing mitochondrial fission and necroptosis.

Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation

The paper examines the temporal response to maternal pulmonary immune activation across maternal and fetal organs using multi-omics, finding that the placenta protects the fetus through metabolic adaptations rather than immune responses.

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancers

This study identifies a SNP that affects Wnt4 expression in endometrial stroma, linking it to pregnancy, endometriosis, and reproductive cancers through differential gene regulation.

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst and stromal cell decidualization in mice.

This study shows that uterine-specific SIRT1 deficiency in mice leads to premature uterine aging, impaired blastocyst invasion, and defective decidualization, linking these issues to hormonal signaling and epigenetic changes.

Inserting Cre Recombinase into the Prolactin 8a2 gene for Decidua-Specific recombination in Mice

This paper develops a mouse strain with decidua-specific Cre recombinase expression to study decidualization and infertility.

Uterine injury during diestrus leads to embryo spacing defects and perturbations in the COX pathway in subsequent pregnancies

This study shows that uterine injury during diestrus in mice causes embryo spacing defects and COX pathway disruptions, leading to placental and embryonic developmental issues.

Delayed implantation induced by letrozole in mice

This study establishes a new delayed implantation model in mice using letrozole and estradiol to investigate the effects of implantation delay on late pregnancy events.

Investigation of Human Endogenous Retrovirus-K (ERVK) Expression and Function in Normal Placentation and Preterm Pregnancy

This study examines ERVK11q23.3 expression in placental tissues, finding it upregulated in preterm placenta, expressed by trophoblasts, and involved in immune responses linked to preterm birth.

Modulation of endometrial E-Cadherin and N-Cadherin by ovarian steroids and embryonic stimuli

This study investigates how estrogen and progesterone modulate E-Cadherin and N-Cadherin expression in mouse endometrial epithelium and its response to embryonic stimuli.

Single-cell analysis of prostaglandin E2-induced decidual cell differentiation: does extracellular 8-Br-cAMP cause artifacts?

This study compares PGE2 and cAMP-based protocols for inducing decidualization in human endometrial stromal fibroblasts, finding that PGE2 induces a more physiologically relevant transcriptomic response.

PAEP and cilia gene splicing changes in endometrial glands during the implantation window in women with recurrent pregnancy loss

This study identifies splicing changes in cilia and PAEP genes in endometrial glands of women with recurrent pregnancy loss, suggesting potential biomarkers for endometrial dysfunction.

Spatio-temporal coordination at the maternal-fetal interface promotes trophoblast invasion and vascular remodeling in the first half of human pregnancy

The paper constructs a spatiotemporal atlas of the maternal-fetal interface using multiomic data to show how gestational age influences immune and stromal cell interactions and spiral artery remodeling.

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Endometrial assembloids of gland organoids and stromal cells reproduce midluteal cell states by scRNA-seq. Senescent decidual cells, tuned with dasatinib, track with whether co-cultured human blastocysts expand or stall.

Exometabolomic analysis of decidualizing human endometrial stromal and perivascular cells

The paper analyzes the exometabolome of decidualizing human endometrial stromal and perivascular cells to identify differentially secreted metabolites and their metabolic pathways during decidualization.

Risk of recurrent pregnancy loss in the Ukrainian population using a combined effect of genetic variants

The paper evaluates a genetic risk score for recurrent pregnancy loss in a Ukrainian population, finding it significantly associated with increased risk.

WNK1 regulates uterine homeostasis and its ability to support pregnancy

This study identifies WNK1's role in uterine homeostasis and pregnancy by showing its regulation of AKT signaling through PP2A in endometrial cells.

Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantation

The paper models human embryo implantation using blastocysts and endometrial epithelial cells, showing EEC-induced syncytiotrophoblast differentiation as the mechanism for embryonic invasion.

Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation

This study shows that cannabinoid receptor signaling is essential for primary decidual zone formation in mice, which is critical for successful pregnancy.

High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a

The paper shows high-quality human embryos secrete miR-320a, which promotes endometrial stromal cell migration, suggesting miR-320a could improve IVF success.

Hyaluronan-NK cell Interaction Controls the Primary Vascular Barrier during Early Pregnancy

This study shows that hyaluronan regulates vascular remodeling and NK cell function during early pregnancy, affecting implantation success.

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window

The paper links a pro-senescent decidual response during the peri-implantation window to recurrent pregnancy loss, showing that immune surveillance failure leads to progesterone-resistant cells and increased miscarriage risk.

Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.