Skin and Cellular Biology Research

The tail domain of neurofilament light chain accumulates in neuronal nuclei during oxidative injury

The paper shows that the tail domain of NFL accumulates in neuronal nuclei during oxidative injury, interacting with DNA and suggesting a role in gene regulation.

CDK12 is Necessary to Promote Epidermal Differentiation through Transcription Elongation

This study shows CDK12 is essential for epidermal differentiation by promoting transcription elongation of key differentiation genes.

BBLN-1 is essential for intermediate filamentorganization and apical membrane morphology

The paper identifies BBLN-1 as a regulator of lumen morphology in C. elegans intestine and identifies its mammalian ortholog bublin, which can compensate for its loss.

Plectin Ensures Intestinal Epithelial Integrity and Protects Colon Against Colitis

This study shows that plectin is essential for intestinal epithelial integrity and protects against colitis by maintaining mechanical stability and junctional function.

Separation of coiled-coil structures in lamin A/C is required for elongation of the filament

This study investigates how mutations affecting the eA22 interaction in lamin A/C impact the separation of coiled-coil structures and filament elongation.

Growth stage-dependent changes of the levels of keratin 1 and keratin 10 as well as the green autofluorescence of the skin of the back and the ears of C57BL/6 mice under basal conditions and after UVC irradiation

A Mechanism for Neurofilament Transport Acceleration through Nodes of Ranvier

The paper develops a stochastic model to explain how neurofilament transport is accelerated at nodes of Ranvier due to increased proximity to microtubule tracks.

Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo

This study shows that desmoplakin is essential for epidermal integrity and morphogenesis in Xenopus laevis embryos by regulating cell movement and differentiation.

Splicing and epigenetic factors jointly regulate epidermal differentiation

The paper identifies ZMAT2 as a regulator of human epidermal differentiation through interactions with epigenetic modifiers and the pre-spliceosome, highlighting joint control of cell adhesion genes.

Intermediate filaments EXC-2 and IFA-4 Maintain Luminal Structure of the Tubular Excretory Canals in Caenorhabditis elegans

The paper shows that EXC-2 and IFA-4 intermediate filaments maintain the structure of C. elegans excretory canals by preventing swelling and guiding tubule growth.

Vimentin Plays A Functional Role In Mammary Gland Regeneration

This study shows vimentin supports mammary gland development and stem cell function in mice and breast cancer cells by affecting ductal outgrowth, cell proportions, and tumor sphere formation.