Skin and Cellular Biology Research

Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.

The paper shows actomyosin forces cause desmoplakin to change conformation in desmosomes, revealing its mechanosensitivity.

Epidermal Stem Cells Control Periderm Injury Repair via Matrix-Driven Specialization of Intercellular Junctions

This study shows that epidermal stem cells regulate periderm injury repair by forming specialized intercellular junctions through interactions with the extracellular matrix.

Hemidesmosomes regulate epidermal differentiation during embryogenesis

This study shows that hemidesmosomes regulate epidermal differentiation by promoting basal cell retention during embryogenesis through both mitotic and non-mitotic mechanisms.

Under pressure: Keratin 9 regulates mechanosensitive YAP1 signaling in palmoplantar epidermis

This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.

The ancient metazoan cytoplasmic intermediate filament protein, Cilin, shapes cilia arrangement and tissue architecture

This study identifies and characterizes Cilin, an ancient metazoan intermediate filament protein, showing its role in cilia arrangement and tissue architecture across ctenophores and other animals.

Desmoplakin tail domain position in the desmosomal plaque is isoform dependent

The paper investigates the architectural arrangement of desmoplakin isoforms in desmosomes using dSTORM and shows that tail domain position correlates with rod length.

The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology

This study identifies the Kelch 3 motif on gigaxonin as critical for its interaction with NUDCD3 and regulation of vimentin filament morphology.

Impaired autophagic flux in skeletal muscle of plectin-related epidermolysis bullosa simplex with muscular dystrophy

This study identifies impaired autophagic flux in skeletal muscle of EBS-MD patients and plectin-deficient models, linking it to protein aggregation pathology.

Continuous self-repair protects vimentin intermediate filaments from fragmentation

This study investigates the mechanism of vimentin filament disassembly, revealing continuous self-repair and subunit exchange dynamics that prevent fragmentation.

Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments

This study develops optogenetic and chemical genetic tools to rapidly manipulate vimentin intermediate filaments and examines their immediate effects on cellular structures.

SERPINB5-TGF-β signalling modulates desmoplakin membrane localization and ameliorates pemphigus vulgaris skin blistering

This study shows that SERPINB5 modulates TGF-β signaling to stabilize desmoplakin and prevent pemphigus vulgaris blistering.

Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease

The paper identifies Ect2 as a binding partner of desmoplakin, showing its role in maintaining RhoA activity at cell junctions and linking it to Carvajal disease pathology.

Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification

This study shows that loss of PRMT5 in skin leads to defective stratification and an atypical keratinocyte population with senescence-like features.

FilaBuster: A Strategy for Rapid, Specific, and Spatiotemporally Controlled Intermediate Filament Disassembly

FilaBuster enables rapid, specific, and spatiotemporally controlled disassembly of intermediate filaments in living cells using a three-step photochemical strategy.

Phase separated liquid vimentin droplets stabilize actin fibers through wetting

This study shows vimentin forms liquid droplets that stabilize actin fibers by wetting them, and this behavior is observed in both a mutant and wild-type vimentin.

Plectin Regulates Focal Adhesion Dynamics and Cytoskeletal Organization in Mouse Astrocytes: Implications for Reactive Astrogliosis

Transport and Organization of Individual Vimentin Filaments Within Dense Networks Revealed by Single Particle Tracking and 3D FIB-SEM

This study uses single-particle tracking and 3D FIB-SEM to reveal dynamics and organization of individual vimentin filaments within dense networks, showing bidirectional motion and minimal local co-alignment with microtubules.

Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes

The paper investigates how neurofilament tail sequence and phosphorylation affect protein brush conformation using reconstituted brushes and theoretical models.

Fisetin extends lifespan in a murine model of recessive dystrophic epidermolysis bullosa

This study shows fisetin extends lifespan and reduces senescent cells in a mouse model of RDEB.

The umbrella cell keratin network: organization as a tile-like mesh, formation of a girded layer in response to bladder filling, and dependence on the plectin cytolinker

This study investigates the organization and response of the keratin network in bladder umbrella cells to mechanical stress, revealing a tile-like structure dependent on plectin.

CK1α, FAM83H, and FAM83B contribute to bundling of neurofilaments and are sequestered in cellular and mice models of ARSACS

The paper identifies CK1α, FAM83H, and FAM83B as contributors to neurofilament bundling in ARSACS and shows their upregulation and co-localization in affected cells.

Diseased skin dermal proteomic profiles reflect shared extracellular matrix dysregulation patterns

The paper identifies shared extracellular matrix dysregulation patterns in dermal fibroblasts across different skin diseases through proteomic analysis.

Formation of vimentin biomolecular condensate-like structures under oxidative stress

This study shows that oxidative stress induces reversible vimentin filament remodeling into biomolecular condensate-like structures, potentially protecting cells from oxidative damage.

Molecular and Mechanical Signatures Contributing to Epidermal Differentiation and Barrier Formation

The paper identifies molecular and mechanical features of intermediate and granular cells in epidermal development, showing contractility drives granular fate and barrier formation.

Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

This study shows that vimentin cytoskeleton assembly is sensitive to net charge states and Coulomb repulsion, with hypotonic stress causing rapid disassembly due to reduced charge screening.

Seven naturally variant loci serve as genetic modifiers of Lamc2jeb induced non-Herlitz Junctional Epidermolysis Bullosa in mice

The paper identifies six additional QTL that modify disease in Lamc2jeb/jeb mice, expanding the understanding of genetic modifiers of EB.

Glucose modulates transcription factor dimerization to enable tissue differentiation

This study shows glucose acts as a morphogen that modulates transcription factor dimerization during tissue differentiation.

ID1 and CEBPA Coordinate Epidermal Progenitor Cell Differentiation

This study identifies ID1 as a key regulator of epidermal progenitor cell differentiation, showing its role in balancing proliferation and differentiation through interactions with CEBPA and bHLH transcription factors.

Revisiting the significance of keratin expression in complex epithelia

The paper reanalyzes single-cell RNA-seq data to confirm and extend understanding of keratin gene expression patterns in epithelial tissues.

Uman Type NF-L Antibodies Are Effective Reagents for the Imaging of Neurodegeneration

The paper demonstrates that Uman type NF-L antibodies specifically detect degenerating neurons and processes in spinal cord injury models, revealing insights into NF-L epitopes and neurodegeneration mechanisms.