Blood groups and transfusion

Determinants of Blood Group Antigen Expression and Prediction of Phenotypes by Machine Learning

The paper identifies structural and biophysical determinants of blood group antigen expression and uses machine learning to predict variant effects on antigenic and null phenotypes.

Predicting Risk of Transfusion-Induced Red Blood Cell Alloimmunization Using Statistical and Machine Learning Approaches in the Recipient Epidemiology and Donor Evaluation Study (REDS-III) Database

This study builds prediction models for RBC alloimmunization using statistical and machine learning methods on the REDS-III database, finding XGBoost provides the best performance with an AUC-ROC of 0.752.

Red Blood Cell Transfusion is a Non-Canonical Immune Stimulus Characterized by the Suboptimal Induction of CD4+ T Cell Help

This study shows that RBC transfusion induces weak IgG class switching compared to vaccination, due to suboptimal T cell help, and activates T cells via a non-canonical pathway.

Resolving RH and GYP hybrid alleles while accessing the entire blood group genome with Nanopore adaptive sampling

This study evaluates adaptive sampling for resolving complex blood group variants using long-read sequencing, identifying novel alleles and hybrid haplotypes in RH and MNS systems.

CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2

This study shows that CDDO-Im, an Nrf2 activator, reduces RBC alloimmunization to the KEL antigen by suppressing IFNβ-stimulated gene expression and promoting RBC recovery in mice.

Splenic MARCO+ marginal zone macrophages regulate rapid production of MCP-1 and KC but are dispensable for alloantibody generation in response to stored RBCs in a murine model.

This study shows splenic MARCO+ marginal zone macrophages (MZMs) enhance cytokine production but are not required for anti-RBC alloantibody generation after stored RBC transfusion in mice.

Transfusion of allogenic murine HOD red blood cells preferentially induces low-affinity, short-lived IgG antibodies that are germinal center independent

Disparities in ABO Blood Type Determination Across Diverse Ancestries: A Systematic Review and Validation in the All of Us Research Program

This study identifies issues with ABO blood type determination using tSNPs across diverse ancestries and validates findings in the All of Us Research Program.

A comprehensive characterization of blood group antigen variants in the Middle Eastern population genomes - Insights into genetic epidemiology

This study characterizes blood group antigen variants in Middle Eastern populations using genomic data, identifies clinically significant alleles, and develops an online resource for transfusion research.

Landscape of blood group antigens and alleles in the Indian population from whole genome sequences

This study analyzes whole genome sequences of 1029 Indian individuals to characterize blood group antigens and alleles, identifying rare phenotypes and comparing them with global populations.

A Pilot Study Using AI for Genetic Effects on Personality: ABO Blood Type in Japan/Korea

This pilot study uses AI and traditional methods to examine the link between ABO blood type and self-reported personality traits in Japanese and South Korean surveys, finding a consistent relationship.

Genetic variants of human platelet antigens in the Indian population from 1029 whole genomes

The paper analyzes genetic variants of human platelet antigens in 1029 Indian genomes to determine allele frequencies and compare them to global populations.

The impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola

The paper examines the association between ABO/Rh blood groups and COVID-19 severity and hospitalization in Luanda, Angola, finding higher risks for blood group O and Rh-positive individuals.

RBCeq: An Integrated Bioinformatics Algorithm Designed to Improve Blood Type Compatibility Testing

RBCeq is a bioinformatics tool that improves blood type compatibility testing by accurately identifying blood group variants from genomic data, achieving high concordance with established databases.

"Prevalence of of ABO and Rhesus (Rh) Blood Groups in Eastern UP Population"

The paper analyzes ABO and Rh(D) blood group frequencies in 200 individuals from Uttar Pradesh, finding B>O>A>AB phenotypes and 20% Rh-negative allele frequency.

A Study of Association of ABO Blood Group types with Cancer Risk

The paper investigates the association between ABO blood group types and cancer risk using case-control data from 243 cancer patients and 250 controls.

Bacterial fucosidase enables the production of Bombay red blood cells

This paper describes a method using bacterial fucosidase to produce H antigen-deficient red blood cells for transfusion to individuals with anti-H antibodies.