Parasitic Diseases Research and Treatment

Molecular basis of differential parasitism between non-encapsulated and encapsulated Trichinella revealed by a high-quality genome assembly

The paper presents a high-quality genome assembly of non-encapsulated Trichinella and identifies genomic and epigenomic factors contributing to differences in parasitism between clades.

Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes

This study shows that ivermectin inhibits extracellular vesicle secretion from parasitic nematodes, suggesting a potential mechanism for its therapeutic effect against lymphatic filariasis.

Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons

The paper uses long-read RNA sequencing to improve gene models and discover operons in two filarial parasites, enhancing functional annotation and target identification.

Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

The paper models the metabolic interactions between a parasitic worm and its bacterial endosymbiont to identify potential drug targets.

Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression

The paper identifies unencapsulated miRNAs secreted by Trichinella spiralis muscle stage larvae that may influence host gene expression.

Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting

The paper develops a motif prediction pipeline to identify regulatory motifs in Brugia malayi, focusing on those involved in the L3-L4 molt stage.

Development of a multiplexed qPCRs-based approach for the diagnosis of Dirofilaria immitis, D. repens, Acanthocheilonema reconditum and the others filariosis

The paper develops a multiplexed qPCR approach to diagnose and differentiate filarial infections in dogs, showing high sensitivity and specificity for detecting filariae and their Wolbachia endosymbionts.

Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi

The paper characterizes the GPI-anchored proteome of Brugia malayi using computational and experimental methods, identifying potential targets for anthelmintic therapies.

Onchocerciasis-associated epilepsy in the Democratic Republic of Congo: Clinical description and relationship with microfilarial density

This study examines onchocerciasis-associated epilepsy in the DRC, finding a link between microfilarial density and seizure frequency, along with clinical features like nodding seizures and Nakalanga features.

Reduced variation in Wolbachia density of larval stages in comparison with adults of Onchocerca volvulus: implications for clinical outcome of infection?

The paper estimates Wolbachia density in different life stages of Onchocerca volvulus and finds lower variation in microfilariae and vector stages compared to adults.

Wolbachia control stem cell behavior and stimulate germline proliferation in filarial nematodes

This study shows Wolbachia controls germline stem cell behavior and stimulates proliferation in filarial nematodes, maintaining quiescence and egg production.

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

This study uses genome-wide analysis to show that genetic drift and soft selective sweeps, rather than strong selection, drive loss of ivermectin sensitivity in Onchocerca volvulus.