Nuclear Structure and Function

A synthetic biology platform for the reconstitution and mechanistic dissection of LINC complex assembly

This paper introduces a synthetic biology platform to reconstitute and study LINC complex assembly using artificial nuclear membranes and cell-free expression.

Observation of histone nuclear import in living cells: implications in the processing of newly synthesised H3.1 & H4

The paper uses a tether-and-release system to study the nuclear import of histones H3.1 and H4, showing they are monomeric in the cytosol and interact with importin-β proteins.

Lamins organize the global three-dimensional genome from the nuclear periphery

This study shows that lamins maintain TAD-TAD interactions and regulate chromatin domain interactions, which are correlated with transcription changes in mouse ES cells.

Depolymerized lamins link nuclear envelope breakdown to mitotic transcriptional quiescence

This study identifies depolymerized LMNA as a mediator of mitotic transcriptional quiescence by linking nuclear envelope breakdown to transcriptional repression.

Distinct ‘safe zones’ at the nuclear envelope ensure robust replication of heterochromatic chromosome regions

The paper identifies Bqt4-rich nuclear subdomains that prevent replication-transcription conflicts and ensure faithful heterochromatin reassembly in fission yeast.

A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

The paper identifies a SUMO-dependent feedback loop that regulates NPC subunit biogenesis by sensing NPC integrity through Ulp1 and Hek2.

Dynein Pulling Forces On Ruptured Nuclei Counteract Lamin-Mediated Nuclear Envelope Repair Mechanisms In Vivo

This study shows that dynein forces on ruptured nuclei counteract lamin-mediated nuclear envelope repair in C. elegans embryos, affecting NE rupture duration and recovery.

Expression of lamina proteins Lamin Dm0 and Kugelkern suppresses stem cell proliferation

This study shows that Lamin Dm0 and Kugelkern suppress intestinal stem cell proliferation in Drosophila by inhibiting Jak/Stat signaling.

PWWP INTERACTOR OF POLYCOMBS (PWO1) links PcG-mediated gene repression to the nuclear lamina in Arabidopsis.

This study identifies PWO1 as a novel PRC2-associated component in Arabidopsis that links PcG-mediated gene repression to the nuclear lamina through physical interaction with CRWN1.