Heme Oxygenase-1 and Carbon Monoxide

Sensitivity of Human Coronaviruses (HCoVs) to Heme Metabolism: Mechanisms Underlying Antiviral Effects

This study investigates how modulating heme metabolism affects infection by seasonal human coronaviruses, finding that protoporphyrin IX directly inactivates the viruses rather than heme degradation pathway components.

Hydrogen sulfide-mediated vasodilation requires heme oxygenase-derived carbon monoxide

This study shows that hydrogen sulfide-induced vasodilation depends on heme oxygenase-2-derived carbon monoxide and TRPV4 channels in endothelial cells.

Non-Canonical Heme Oxygenase-1 Function in Hematopoietic Stem Cell Homeostasis and Aging

This study shows that HO-1 has a non-canonical, cell-intrinsic role in regulating HSC homeostasis, differentiation, and aging by affecting genome maintenance, apoptotic signaling, and RNA metabolism.

Treatment with 2-phospho-L-ascorbic acid mitigates biochemical phenotypes of heme oxygenase 1 deficiency

This study shows that 2-phospho-L-ascorbic acid treatment improves mitochondrial function and reduces cytotoxicity in HO-1 deficient cells.

Activation of Heme Metabolism Promotes Tissue Health after Intraarticular Injury or Surgical Exposure

This study shows that activating heme metabolism via carbon monoxide reduces oxidative damage and improves joint health after injury.

Regulation of BACH1 by hemin improves cardiac function in a mouse model of myocardial infarction

This study shows hemin treatment reduces BACH1 and increases HMOX1 in a mouse MI model, improving cardiac function and vascular density.

Pilot MRI study of carbon monoxide (CO) against ischemic stroke in mice: blood brain barrier integrity and metabolic pattern

This study investigates the neuroprotective effects of carbon monoxide (CO) in mice after ischemic stroke using MRI, showing improved blood-brain barrier integrity and metabolic patterns.

Phenotypic associations with the HMOX1 GT(n) promoter repeat in European populations

This study imputed HMOX1 GT(n) repeat length in European cohorts and found no significant phenotypic associations despite high imputation accuracy.

Zebrafish heme oxygenase 1a is necessary for normal development and macrophage migration

This study investigates the role of zebrafish hmox1a and hmox1b in development and macrophage migration, finding that hmox1a has a conserved function similar to mammalian Heme oxygenase 1.

NR4A3 is oxidative stress responsible transcription factor through HMOX1, and also controls cell cycle through CCNE1 and CDK2 in pancreatic islet derived 1.1B4 cells