Thermal Regulation in Medicine

SARAF represses the mild hypothermia response through the regulation of JUN

This study identifies SARAF as a repressor of the mild hypothermia response by regulating JUN and calcium dynamics, showing its role in cytoprotection against hypoxia.

Capsinoids (non-pungent TRPV1 agonists) promote mild hypothermia and improved outcome following stroke in aged mice

This study shows that capsinoids induce mild hypothermia in aged mice after stroke, reducing brain injury and improving survival and functional outcomes.

PGE2 modulation of stimulus valence directs zebrafish behavioral fever

This study shows that PGE2 alters temperature stimulus valence in zebrafish, making heating attractive and cooling aversive, challenging the idea that fever reduces perceived warmth.

Neuromodulation of Foxp2+ hypothalamic neurons induces therapeutic hypothermia

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

Targeted preoptic neuronal activation induces a hypothermic state with metabolic reprogramming and acute cerebroprotection

The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.

Relationship between Brain and Body Temperature in Anesthetized Animals Measured by Ultralocal Thermometry

This study examines the relationship between brain and body temperature in anesthetized animals using ultralocal thermometry, revealing non-linear dynamics and two distinct temperature response phases.

Selective brain cooling monitored by CT perfusion as adjuvant therapy in a porcine model of severe ischemic stroke

This study demonstrates that selective brain cooling using VINCI can reduce subacute injuries in a porcine model of severe ischemic stroke when guided by CT perfusion imaging.

Molecular Pathways Resultant in Fever due to Inhibitory Effects of Binding PGE2 to Glucocorticoid Receptors

The paper identifies molecular pathways causing fever through competitive inhibition of PGE2 and CORT at glucocorticoid receptors using mathematical modeling and case study validation.

Selective Brain Hypothermia Ameliorates Focal Cerebral Ischemia-Reperfusion Injury via Inhibiting Fis1 in Rats

This study shows that selective brain hypothermia reduces Fis1 expression, which mitigates focal cerebral ischemia-reperfusion injury in rats.