Thermal Regulation in Medicine

SARAF represses the mild hypothermia response through the regulation of JUN

This study identifies SARAF as a repressor of the mild hypothermia response by regulating JUN and calcium dynamics, showing its role in cytoprotection against hypoxia.

Targeted Intestinal Cooling Offers Superior Brain Protection in the Mouse Stroke Model

This study evaluates targeted intestinal cooling (CC) versus body surface cooling (SC) and normothermia (NT) in a mouse stroke model, finding CC significantly reduces brain injury and improves survival and function.

Capsinoids (non-pungent TRPV1 agonists) promote mild hypothermia and improved outcome following stroke in aged mice

This study shows that capsinoids induce mild hypothermia in aged mice after stroke, reducing brain injury and improving survival and functional outcomes.

PGE2 modulation of stimulus valence directs zebrafish behavioral fever

This study shows that PGE2 alters temperature stimulus valence in zebrafish, making heating attractive and cooling aversive, challenging the idea that fever reduces perceived warmth.

Neuromodulation of Foxp2+ hypothalamic neurons induces therapeutic hypothermia

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

Targeted preoptic neuronal activation induces a hypothermic state with metabolic reprogramming and acute cerebroprotection

The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.

Artificially induced torpor during pregnancy impairs fetal growth in mice

This study shows that artificially induced hypothermia during pregnancy in mice causes fetal growth impairment and pregnancy loss, highlighting the importance of maternal body temperature in fetal development.

A simple, inexpensive battery-powered homeothermic warming pad for mice and rats

The paper describes a low-cost, battery-powered warming pad for mice and rats to maintain core body temperature during anesthesia, showing it can keep animals normothermic for over 6 hours.

Relationship between Brain and Body Temperature in Anesthetized Animals Measured by Ultralocal Thermometry

This study examines the relationship between brain and body temperature in anesthetized animals using ultralocal thermometry, revealing non-linear dynamics and two distinct temperature response phases.

Selective brain cooling monitored by CT perfusion as adjuvant therapy in a porcine model of severe ischemic stroke

This study demonstrates that selective brain cooling using VINCI can reduce subacute injuries in a porcine model of severe ischemic stroke when guided by CT perfusion imaging.

A low-cost mouse cage warming system provides improved intra-ischemic and post-ischemic body temperature control &ndash: application for reducing variability in experimental stroke studies

This paper describes a low-cost mouse cage warming system that improves temperature control during and after stroke experiments, reducing variability in outcomes.

Molecular Pathways Resultant in Fever due to Inhibitory Effects of Binding PGE2 to Glucocorticoid Receptors

The paper identifies molecular pathways causing fever through competitive inhibition of PGE2 and CORT at glucocorticoid receptors using mathematical modeling and case study validation.

Selective Brain Hypothermia Ameliorates Focal Cerebral Ischemia-Reperfusion Injury via Inhibiting Fis1 in Rats

This study shows that selective brain hypothermia reduces Fis1 expression, which mitigates focal cerebral ischemia-reperfusion injury in rats.