Digital Holography and Microscopy

Label-free acoustic and optical microscopy of live tumor spheroids in hydrogel for high-throughput 3D In-vitro drug screening

This paper combines label-free acoustic and optical microscopy to image 3D tumor spheroids in hydrogels, enabling high-throughput drug screening by capturing structural and cellular details.

Label-free 3D subcellular phenotyping of mouse embryos by holotomography enables early prediction of blastocyst formation

This paper introduces a label-free 3D imaging technique to predict blastocyst formation in mouse embryos using machine learning.

CellSNAP: A fast, accurate algorithm for 3D cell segmentation in quantitative phase imaging

CellSNAP improves 3D cell segmentation in quantitative phase imaging by being faster, more robust, and better at handling clumped cells and interferogram drifts.

High-resolution label-free transcranial imaging of in vivo neural activity via interferometric measurement of tissue deformation

This paper demonstrates a holographic imaging system that non-invasively records in vivo neural activity through high-resolution measurement of tissue deformation.

Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids using low-coherence holotomography

This study introduces low-coherence holotomography for long-term live imaging of unlabeled mouse small intestinal organoids, capturing high-resolution morphological details and differentiating viable from non-viable organoids.

Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs

This study uses dry mass and volume measurements to assess early response of multiple myeloma cells to proteotoxic and genotoxic treatments, finding dry mass increases correlate with bortezomib sensitivity.

Circadian volume changes in hippocampal glia studied by label-free interferometric imaging

The paper uses label-free interferometric imaging to show that hippocampal astrocyte volume decreases by 25% during the night while maintaining constant dry mass.

In vivo fluorescence imaging with a flat, lensless microscope

This paper demonstrates in vivo fluorescence imaging with a flat, lensless microscope achieving high spatial resolution and large field of view.

Label-free monitoring of 3D cortical neuronal growth in vitro using optical diffraction tomography

This paper introduces a label-free method to monitor 3D neuronal growth in vitro using optical diffraction tomography, enabling visualization of neurite outgrowth without fixation.

Label-free screening of brain tissue myelin content using phase imaging with computational specificity (PICS)

The paper uses phase imaging combined with AI to quantify myelin content in brain tissue, showing high accuracy in distinguishing gestational size and diet type.

Interpretable Deep Learning for Breast Cancer Cell Phenotyping Using Diffraction Images from Lens-Free Digital In-Line Holography

HoloNet is a deep learning model that analyzes holographic images of breast cancer cells to classify cell types and quantify molecular markers, identifying new subtypes.

Quantifying myelin content in brain tissue using color spatial light interference microscopy (cSLIM)

The paper quantifies myelin content in brain tissue using cSLIM, showing differences between AGA and SGA piglets and the effect of diet on myelination.

Computationally Enhanced Quantitative Phase Microscopy Reveals Autonomous Oscillations in Mammalian Cell Growth

This paper introduces a new computational method for Quantitative Phase Microscopy to measure single-cell growth dynamics, revealing oscillatory growth patterns in mammalian cells.

Genetic manipulation of the optical refractive index in living cells

This paper demonstrates the manipulation of the optical refractive index in mammalian cells using cephalopod reflectin protein nanoparticles and shows their application in microscopy techniques.

How neurons move during action potentials

This study uses high-resolution imaging to show how neurons deform during action potentials, revealing the relationship between electrical signals and mechanical changes.

One-Shot phase-recovery using a Cellphone RGB Camera on a Jamin-Lebedeff Microscope

The paper presents a one-shot phase-recovery method using a cellphone RGB camera on a Jamin-Lebedeff microscope to enable real-time quantitative phase measurements.

96 Eyes: Parallel Fourier Ptychographic Microscopy for high-throughput screening

The paper introduces a parallel microscopy system called 96 Eyes that enables simultaneous imaging of all wells on a 96-well plate using Fourier Ptychography to enhance imaging quality and depth of field.

Measurements of morphological and biochemical alterations in individual neuron cells associated with early neurotoxic effects in Parkinson’s disease

The paper uses optical diffraction tomography to measure morphological and biochemical changes in individual neurons from an in vitro Parkinson’s disease model, revealing early apoptotic features.