Axon Guidance and Neuronal Signaling

Dynamic endothelial ephrin-B2 and EphB4 expression characterizes hyaloid vessel regression

The paper shows that during hyaloid vessel regression in mice, endothelial cells shift from ephrin-B2 to EphB4 expression, with Notch1 deletion altering this transition and affecting apoptosis and proliferation.

Temporal tuning of actin nucleation by the repurposed DNA repair complex RAD51/fignl1 encodes distinct axon guidance decisions

The paper shows how RAD51/fignl1, repurposed from DNA repair, controls axon guidance by modulating F-actin nucleation timing and magnitude.

VASH1 phosphorylation regulates tubulin detyrosination via CNP/PRKG1α signaling in DRG neurons.

This study identifies VASH1 phosphorylation by PRKG1 as a mechanism regulating tubulin detyrosination in DRG neurons through CNP signaling.

Dishevelled2 Condensates control Axon Initial Segment (AIS) assembly and function through MTCL1-Dependent microtubule recruitment.

This study identifies Dvl2 as a novel component of the axon initial segment (AIS) and reveals its role in AIS assembly through MTCL1-dependent microtubule recruitment.

A Thermodynamic Theory of Axon Guidance: Navigation Through High-Entropy Signaling States

The paper develops a thermodynamic framework to model axon guidance, showing growth cones navigate high-entropy signaling states to achieve persistent movement and branching.

Ultrastructurally planar growth cones during neocortical axon navigation

The paper reconstructs growth cones of callosal projection neurons in the developing mouse brain and finds they have a planar, dorsoventrally oriented morphology with filopodia that precede accelerated axon growth.

A low-adhesion mechanism enables axon growth in the developing brain

This study identifies a low-adhesion mechanism driven by microtubule stabilization that enables rapid axon growth in the developing mouse brain.