Burkholderia infections and melioidosis

Adaptation of Burkholderia cenocepacia to low oxygen drives changes consistent with adaptation to chronic infection

This study shows that long-term hypoxia exposure of Burkholderia cenocepacia leads to proteomic changes and increased virulence traits consistent with adaptation to chronic infection in cystic fibrosis.

Profiling of Burkholderia pseudomallei variants derived from Queensland clinical isolates

The paper profiles Burkholderia pseudomallei variants from clinical isolates to understand colony morphotype variation (CMV) using proteomics and genomics, finding that CMV is driven by regulatory mechanisms rather than genomic mutations.

Co-isolation of genetically distinct Burkholderia pseudomallei strains from a single patient in North Queensland

The paper identifies two genetically distinct Burkholderia pseudomallei strains co-isolated from a single patient and presents their multi-omics characterization.

Genomic Insights into Ceftazidime Resistance in Burkholderia pseudomallei: Discovery of A172T Mutation, and Palindromic GC-Rich Repeat Sequences Facilitating penA Duplication and Amplification.

This study identifies a novel A172T mutation and penA gene duplication driven by PGCRRS as key factors in ceftazidime resistance in Burkholderia pseudomallei.

Quorum sensing and DNA methylation play active roles in clinical Burkholderia phase variation

This study identifies quorum sensing and adenosine DNA methylation as two antagonistic systems controlling phase variation in Burkholderia ambifaria clinical isolates.

Prediction of Burkholderia pseudomallei DsbA substrates identifies potential virulence factors and vaccine targets

The paper predicts Burkholderia pseudomallei DsbA substrates to identify potential virulence factors and vaccine targets using genomic analysis and homology searches.

Genome Sequences of Burkholderia thailandensis strains E421, E426, and DW503

The paper reports the draft genome sequences of three Burkholderia thailandensis strains, providing their contig counts, lengths, and GC content.

Tracing the environmental footprint of the Burkholderia pseudomallei lipopolysaccharide genotypes in the tropical \"Top End\" of the Northern Territory, Australia

This study uses whole-genome sequencing and geographical mapping to show that lipopolysaccharide (LPS) types in Burkholderia pseudomallei correlate with specific regions in the Northern Territory, Australia, and can serve as geographical markers.

Genome rearrangements and selection in multi-chromosome bacteria Burkholderia spp

The paper analyzes genome rearrangements and selection in Burkholderia species, finding non-random inversion patterns and potential phase variation mechanisms.