Inflammation biomarkers and pathways

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Characterization of the TREM-1 Signaling Landscape in Human Neutrophils

This study identifies kinome activity and transcriptomic changes in human neutrophils after TREM-1 activation, revealing potential kinase targets for inflammatory and cancer therapies.

Pan-TREM-1 versus macrophage-restricted TREM-1 blockade in cancer and other inflammatory pathologies

This study compares the efficacy of pan-TREM-1 and macrophage-restricted TREM-1 blockades in cancer and inflammatory diseases, showing differences in therapeutic outcomes based on treatment timing and disease context.

G-CSF and IL-6 drive myeloid dysregulation during severe viral infection

This study identifies G-CSF and IL-6 as drivers of myeloid dysregulation during severe viral infection, showing their role in emergency myelopoiesis and tissue injury.

Characterizing a Low-Density Neutrophil gene signature in acute and chronic infections and its impact on disease severity

The paper identifies a 17-gene LDN signature associated with disease severity in acute infections through meta-analysis and validation in RNA-seq and proteomics datasets.