Discover, rate, and discuss biology preprints.

The paper infers patient-specific metabolic fluxes in breast cancer using metabolic models and machine learning, showing they reflect molecular subtypes and heterogeneity but not clinical features.

This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance angiogenesis in a pre-clinical model, suggesting their potential as a pro-angiogenic nanotherapeutic for bone repair.

This paper describes a novel biochemical pathway using a phosphatase to reverse the Leloir pathway in E. coli, enabling direct tagatose synthesis from glucose with high yield.

This paper develops a high-throughput qFRET method to determine protein interaction affinity without purification, revealing a two-enzyme co-recognition mechanism for SUMOylation substrates.

This study develops sweeping antibodies against IL-16, showing improved antigen clearance compared to conventional antibodies.

This paper evaluates contrast agents for in vivo fluorescence detection of circulating tumor cells, finding that while they show high uptake, they also label non-cancer cells, reducing specificity.

This study examines how shear stress and pressure affect pulmonary arterial endothelial cells in health and PAH, revealing divergent transcriptional responses across disease states and donor sex.

This study identifies peak anteroposterior heel slip acceleration as a predictor of lateral trunk flexion during unexpected slips, suggesting it as an early destabilizing mechanism.

This paper designs a potent Wnt surrogate specific for Fzd7 subtype members, showing strong binding affinity and functional activity in organoid formation and hair regeneration.

This paper engineers E. coli to secrete a thermophilic cellulase cocktail that functions in seawater, achieving high yields and activity for lignocellulosic bioprocessing.

This study uses ProteinMPNN to redesign AAV2 capsid proteins, resulting in functional variants with altered cores and interfaces while retaining transduction efficiency.

This study compares the characteristics of cultivated beef meat made from different beef types with their original meat, showing similarities and unique properties in fatty acid composition.

This study shows nanovibrational stimulation promotes osteogenesis in mesenchymal stromal cells via non-canonical Wnt signaling and BCL3 regulation.

This study shows that adaptive immunity influences regional aortic remodeling in hypertension by modulating perivascular adipose tissue plasticity and immune-metabolic interactions.

This study screens TCR-based CAR designs to improve anti-tumor efficacy by incorporating CD28 and CD27 costimulatory domains, showing enhanced performance in mouse tumor models.

This paper validates computational fluid dynamics predictions of particle trajectories in microfluidic cross-slot junctions using a novel fabrication method combining injection-molding and two-photon polymerization 3D printing.

This study develops a growth model to track hDPC functional recovery and identifies autocrine signaling as critical for maintaining their hair-inductive capacity.

This study shows that APOE knockout reduces vascular graft fibrosis by limiting profibrotic macrophage formation through LRP1, improving aortic compliance and reducing ECM deposition.

The paper introduces PULSE, a device for targeted ultrasound-mediated delivery of drugs and genes in tumors, showing improved transfection and perfusion in vitro and phantom tests.

This study develops circular guide RNAs (cgRNAs) and Cas13d-encoding mRNA for efficient RNA editing of Adar1 in triple-negative breast cancer, showing improved stability and therapeutic efficacy.