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SEC-seq links single-cell transcriptomes with secretion levels by isolating cells and secretions in Nanovials, enabling analysis of secretory phenotypes and their genetic drivers.

This paper develops platelet membrane-coated SPIONs for targeted Paclitaxel delivery and magnetic hyperthermia, showing enhanced tumor uptake and cytotoxicity.

This study shows that adding human iPSC-derived motor neurons to engineered muscle bundles improves their structural and functional maturity and maintains an oxidative phenotype.

This study identifies the optimal frequency for seizure induction in ECT and MST to minimize stimulus intensity and potential adverse effects.

This paper evaluates the cost-benefit and effectiveness of a pipette tip decontamination station, finding it economically viable and 100% efficient in sterilizing tips for reuse.

This study evaluates three methods to improve heart graft assessment during normothermic machine perfusion, showing they can enhance transplant outcomes by better predicting graft viability.

This study investigates how epigenetic mechanisms regulate meniscus cell migration under inflammation, revealing zonal differences and potential therapeutic targets.

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

This paper develops tumor-targeted hydroxyapatite nanoparticles for dual-mode imaging and photothermal cancer therapy, showing effective tumor targeting and prolonged survival in vivo.

This study develops a non-viral gene editing method using circular single-stranded DNA templates and TALEN, showing improved engraftment and long-term gene editing in HSPCs compared to AAV.

This paper introduces a machine learning framework for therapeutic antibody design that integrates computational methods with experimental validation, resulting in significantly improved binding affinity for multiple targets.

This study develops a magnetic bioprinting method to create stretchable, shape-controlled skeletal muscle tissues that maintain their form and enhance maturation through magnetic stimulation.

This study develops a 3D-printed flexible microfluidic device for organ-on-a-chip applications, showing improved cell viability and differentiation compared to conventional methods.

This paper uses robotic visible-light OCT to visualize segmental Schlemms canal anatomy and its response to pilocarpine in mice, showing segmental changes in volume.

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

This study uses WISH-BONE to analyze 3D Sost mRNA and sclerostin distribution in mouse tibia midshafts after mechanical loading, showing region-specific changes and highlighting the method's importance for mechanoadaptation research.

The paper develops a U-Net model to segment mitochondrial networks in endothelial cells using holotomographic microscopy images.

This paper introduces an unsupervised neural network method for bladder endoscopy image stitching, achieving high success rates and robustness in challenging conditions.

This study evaluates biodegradable PDLLA optical fibers as neural interfaces in mice, showing degradation and efficient SW-NIR light transmission with potential for optogenetics and therapy.