Discover, rate, and discuss biology preprints.

The paper introduces a library of metrics for analyzing porosity in packed particle assemblies using LOVAMAP software, revealing relationships between particle properties and void space features.

This paper develops a rapid colorimetric detection method for citrus tristeza virus using portable sample prep and RT-LAMP, achieving high efficiency and reliability in greenhouse settings.

This study identifies a novel antifungal compound targeting ALS, validated through genome mining, biochemical assays, and a mouse model of invasive aspergillosis.

This paper introduces Aviatar, a single-component optogenetic system for inducible protein translocation to various subcellular compartments, demonstrating its utility in regulating actin polymerization and cancer-related signaling.

This study uses fluorescein as an optical clearing agent to enhance OCT imaging depth in scleral tissues, improving transscleral image guidance during surgery.

This study evaluates the impact of ethylene oxide sterilization on PEDOT:PSS electrophysiology electrodes, finding minimal changes in performance and long-term stability.

This paper introduces a modular flow chamber that independently controls substrate stiffness and fluid shear stress to study their combined effects on cell behavior.

This paper develops a 3D-bioprinted scaffold with endothelial progenitor cells and Zn2+-enhanced SFMA/HisMA/nHAP to promote healing of infected bone defects by combining antibacterial, angiogenic, and osteogenic properties.

This study investigates the impact of perchlorate on biocementation-capable bacteria and Martian bricks, finding that perchlorate inhibits bacterial growth and induces multicellularity-like behavior, while improving brick compressive strength with guar gum.

This study develops a framework for cellular-resolution electrical stimulation of neurons using current steering and biophysical models, demonstrating its effectiveness in targeting retinal ganglion cells.

This study develops cell-assembled decellularized adipose tissue scaffolds for co-delivering ASCs and ECFCs to enhance soft tissue regeneration, showing improved ECFC retention and vascular regeneration.

This paper develops enzyme-responsive elastin-like polypeptides to stabilize fibrin clots and restore coagulation in thrombocytopenia by enhancing clot mechanics and reducing blood loss.

This paper presents a 3D-printed, pump-free multi-organ-on-a-chip device that models the intestine-liver-muscle axis by enabling dynamic co-culture of three cell types with improved metabolic functions.

This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.

This study shows that ultrasound-activated nanobubbles reduce tumor stiffness and enhance lipid nanoparticle delivery and immunotherapy efficacy.

This study uses deep learning to segment osteocyte networks and shows it can distinguish between young and aged mouse bones.

This paper describes an in-house Tn5-based plasmid sequencing platform called AistSeq using a compact benchtop sequencer, demonstrating a streamlined workflow for plasmid sequence verification.

Hist2Cell predicts fine-grained transcriptional cell types from histology images with high accuracy, enabling cellular mapping and cancer prognosis.

This study investigates how the extracellular matrix affects AAV gene therapy by comparing diffusion and transduction efficiency across different AAV serotypes and ECM models.