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Continuous Capture of recombinant AAV Particles Using Twin-Column CaptureSMB

This paper introduces a continuous twin-column capture process (CaptureSMB) for purifying rAAV5 directly from perfusion harvest, improving yield and efficiency while maintaining product quality.

Microfluidic Core-Shell Encapsulation Enables Scalable Generation of Apical-Out Intestinal Spheroids

This paper introduces a microfluidic method to generate scalable apical-out intestinal spheroids by encapsulating cells in core-shell hydrogel microcapsules.

Systematic Evaluation of Signal Peptide-Driven Protein Secretion in the Fast-Growing Cyanobacterium Synechococcus sp. PCC 11901

This study evaluates signal peptide-driven protein secretion in Synechococcus sp. PCC 11901, finding that FutA from the Tat pathway outperforms Sec pathways, but optimal selection depends on the target protein.

Structural co-modulation: An individualized measure of inter-component interactions in source-based morphometry

This paper introduces a structural co-modulation measure to quantify individualized interactions between brain components using source-based morphometry, finding reduced co-modulation in schizophrenia patients.

AI-enabled discovery of small molecules targeting complementary pathways for hair follicle rejuvenation

This study uses AI to discover small molecules that rejuvenate hair follicles by targeting complementary pathways, showing increased cell viability and suppression of follicular miniaturization.

Emulating the gingival-tooth interface during bacterial, fungal, and viral infection in a microphysiological model of the human oral cavity

This study develops a microphysiological model of the human oral cavity to study host-microbe interactions during bacterial, fungal, and viral infections.

3D-Printed Scaffolds for Local Chemotherapeutic Delivery in Resected Spine Metastases

This study evaluates 3D-printed composite scaffolds for local chemotherapy delivery in spinal metastases, showing effective drug release and bone integration in animal models.

CORe Designer: a CRISPR design tool for proteome engineering

CORe Designer is a CRISPR tool that allows protein-centric design of guide RNAs and repair templates for proteome engineering, streamlining targeted mutagenesis experiments.

Effects of Left Atrial Wall Thickness on Myocardial Mechanics and Blood Dynamics using Multiscale Modeling

This study uses multiscale modeling to show that left atrial wall thickness significantly affects myocardial stresses and oscillatory shear, more than other factors like cavity volume or displacement.

Receive-Only Coupled Wireless Radiofrequency Probe for Endocavity MR Imaging Using a pTx System

The paper demonstrates a wireless RF resonator probe with a dual-drive pTx system to enhance MRI SNR in a localized region while minimizing transmit-field interactions.

Kombucha-Derived Cellulose Non-wovens: Growth Optimization, Mechanics, and Recycling

This paper optimizes the growth of kombucha-derived cellulose non-wovens, evaluates their mechanical properties after different post-processing methods, and demonstrates their recyclability through enzymatic degradation and electrospinning.

Pulsed electrical stimulation enhances intestinal permeability

This study shows pulsed electrical stimulation increases intestinal permeability by affecting tight junction proteins, potentially enabling better drug absorption.

SPOTTER: Automated Tissue-Barcoding Platform for Spatial Proteomics and Phosphoproteomics

SPOTTER enables automated, high-plex spatial proteomics and phosphoproteomics by barcoding proteins on tissue sections, achieving deep coverage with LC-MS/MS.

HMEC-1 extracellular vesicles as regulators of endothelial cell activation under inflammation

This study isolates and characterizes HMEC-1 extracellular vesicles, showing they enhance wound closure and have dual inflammatory effects on endothelial cells.

A stimuli-responsive ex vivo model of osteoarthritis demonstrates TLR4-mediated cartilage degradation and a Rapamycin-induced fast matrix recovery

This paper develops an ex vivo OA model to study TLR4-mediated cartilage degradation and Rapamycin-induced matrix recovery.

High aspect ratio graphene oxide: a highly efficient plasmid DNA deliverer for plant seed

This paper introduces high aspect ratio graphene oxide (HARGO) as an efficient plasmid DNA delivery method for plant seeds, achieving 90% success in Poa crymophila, wheat, and rice.

Multimodal PET Defines a Goldilocks Thermal Window for Focused Ultrasound Ablation and Immunotherapy Combinations

This paper identifies an optimal thermal dose for focused ultrasound ablation that balances tumor destruction with immunotherapy access using multimodal PET imaging.

Distinct effects of different metabolic stress models on human-derived neuronal networks

This study compares three metabolic stress models on human-derived neuronal networks, showing distinct effects on activity and viability, with limited recovery after reoxygenation.

Modeling Particle Transport In Biomedical Flows Using Implicit Geometry Representations

The paper develops an efficient particle dynamics model using implicit geometry representations to improve computational speed in biomedical flow simulations.

Physiologically Informed PCA-Partial Correlation for highly Collinear Brainstem fMRI Networks

This paper introduces a physiologically informed PCA-regularized partial correlation method to estimate direct brainstem functional connectivity in highly collinear fMRI data, improving robustness and interpretability.