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Aptamer-Targeted PLGA Nanoparticles for Biofilm-Directed Intra-articular Antibiotic Delivery in Prosthetic Joint Infection

This study develops aptamer-targeted PLGA nanoparticles for localized antibiotic delivery in prosthetic joint infections, showing improved biofilm targeting and prolonged drug retention.

Excluded Volume Effect-induced Shrinkage for Resolution Enhancement of Hydrogel Bioconstructs

This paper introduces EVER, a post-processing strategy that enhances hydrogel bioconstruct resolution through shrinkage induced by excluded volume effects, achieving significant dimensional reduction while maintaining cell viability.

A light-responsive lipid nanoparticle platform delivering Cas9 RNP for VEGFA editing suppresses choroidal neovascularisation

This study develops a light-responsive lipid nanoparticle platform for VEGFA gene editing to suppress choroidal neovascularisation, showing reduced vascular leakage and structural abnormalities in a rat model.

Tumor-Associated EDA-FN-Enriched Matrix Instructs Macrophage Behavior

This study develops a fibroblast-derived matrix platform to investigate how tumor-associated EDA-FN-enriched matrices influence macrophage behavior in the tumor microenvironment.

MicroDLP: Microscope-Enabled Resolution-Switchable 3D Microprinting

This paper introduces MicroDLP, a 3D microprinting platform that enables resolution-switchable microfabrication across multiple length scales.

Engineering pH-Responsive trans-Ferulic Acid/κ-Carrageenan Beads for On-Demand Micronutrient Delivery in Plants

This study develops pH-responsive microbeads for targeted micronutrient delivery in acidic soils, improving crop productivity and reducing phytotoxicity.

Rapid thermoforming of polycarbonate cell culture accessories from 3D printed molds

This paper introduces a method to rapidly create customized, autoclavable cell culture accessories using polycarbonate thermoforming from 3D printed molds, demonstrating compatibility with human iPSC culture and differentiation.

CBAM-enhanced MaxViT-Tiny for gastrointestinal endoscopy image classification: Robustness, explainability, and external validation

This paper proposes a CBAM-enhanced MaxViT-Tiny model for GI endoscopy image classification, achieving high accuracy but showing vulnerability to adversarial attacks and unreliable explanations.

Broadband Rheometry of Native Soft Tissues via i-Rheo-Indent

This paper introduces i-Rheo-Indent, a method to measure broadband viscoelasticity of soft tissues without specimen preparation, showing it captures mechanical properties more accurately than conventional methods.

Generic versus personalized foot-ground contact models for predictive simulations of walking: Is personalization worth the effort?

This study compares generic and personalized foot-ground contact models in walking simulations, finding that personalized models improve accuracy in estimating ground reactions and joint loads.

Null Subtraction Imaging for Functional Ultrasound Brain Activation Mapping

This study evaluates Null Subtraction Imaging (NSI) for functional ultrasound brain activation mapping in mice, finding it improves spatial resolution but requires balancing DC offset for temporal stability.

Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC

This study enhances CAR-T cell migration through synthetic cytokine receptors, reducing metastasis in TNBC mouse models.

Mechanical history shapes phenotypic plasticity and fibroblast-autonomous 3D remodeling in iPSC-derived cardiac fibroblasts

This study shows that mechanical culture history affects iPSC-derived cardiac fibroblasts' phenotype and TGF-beta1 response, but later passages can alter these effects.

Plasma-Enabled Multiscale Coupling of Architecture and Biointerfaces Drives Osteogenesis in 3D-Printed Gyroid Scaffolds

This paper demonstrates that coupling nanoscale biointerface features with micro- and macro-scale scaffold architecture synergistically enhances osteogenesis in 3D-printed gyroid scaffolds.

Scalable high-density tactile arenas for measuring ground-contact forces in freely moving animals

This paper introduces a scalable tactile sensing platform to measure ground-contact forces in freely moving animals, detecting changes in limb loading after sciatic nerve injury.

A Real-Time Automated Deep Learning Workflow for Non-invasive High-Magnification Imaging of C. elegans

This paper develops a real-time deep learning workflow for non-invasive high-magnification imaging of C. elegans, enabling stable imaging across magnifications without immobilization.

A Personalized Approach to Student Mental Health: Real-Time EEG Biofeedback for Stress and Focus Management

This paper explores a personalized EEG biofeedback approach for stress and focus management using subject-specific thresholds and a two-channel EEG setup.

An open-source, 3D-printable droplet microfluidics platform with strobe-enhanced microscopy

This paper introduces an open-source, 3D-printable droplet microfluidics platform with stroboscopic microscopy for stable droplet generation and low-flow control.

Nanotherapy-mediated biased antigen-presenting cell reprogramming supports T cell anergy to prevent type 1 diabetes

This paper develops a nanotherapy to reprogram antigen-presenting cells and induce T cell anergy, delaying type 1 diabetes onset in mice.

Interpretable computational SHG microscopy enables quantitative tissue phenotyping of cardiac remodeling in nonischemic heart failure

The paper develops an interpretable computational SHG microscopy framework to classify cardiac remodeling states in mice with high accuracy.