Discover, rate, and discuss biology preprints.

This paper develops a mathematical model to predict TDP-43 inclusion body growth and neurotoxicity over time, showing radius increases with cube root of time and toxicity increases linearly.

The paper evaluates ADMET prediction models on TDC leaderboards, finding most top models lack reproducibility and exhibit data leakage, with only three methods passing rigorous checks.

This study shows that increasing μ-opioid receptor density promotes trafficking via GRK2/3 and β-arrestin interactions, while class B GPCRs block trafficking by sequestering β-arrestin.

This paper shows ionic liquids modulate protein folding by stabilizing or destabilizing folded/unfolded states through distinct mechanisms, challenging the conventional view of protein stabilization.

The paper uses phase-targeting cryofixation to analyze sarcomere length dynamics in rat hearts, revealing contractile state-dependent spatial heterogeneity.

This paper introduces a computational model of the inner mitochondrial membrane that identifies cardiolipin and leak as key regulators of ATP output through parameter sweeps and sensitivity analysis.

The paper uses large-scale simulations to show that intrinsically disordered regions in proteins are structurally and evolutionarily constrained by their full-length protein architecture.

The paper shows a small molecule selectively targets an oligomeric form of a protein with an intrinsically disordered region, altering its interaction network and condensation properties.

This study uses time-resolved single-molecule FRET to show that PAR length determines nucleosome decompaction efficiency and reversibility.

This study investigates the structural and dynamic effects of the m.14849T>C variant in Cytochrome b, showing localized perturbations in the heme bL microenvironment that may contribute to multisystem mitochondrial disease.

This paper reveals that Thanatin inhibits NDM-1 by preserving its zinc center while restricting dynamics, contrasting with zinc-displacement models and showing reduced bacterial viability.

This study uses solid-state NMR to show how NaCl and MgCl2 induce distinct polysaccharide remodeling in the cell wall of Aspergillus atacamensis under hypersaline conditions.

The paper develops a protocol combining segmental deuteration and multi-step protein ligation with SAXS and iCM-SANS to improve discrimination of conformational ensembles in multi-domain proteins.

This paper shows how protein dimerization can enhance or impair DNA target selectivity by redistributing protein populations across the genome, using kinetic models and ChIP-seq data.

This study models the behavior of free electrons in theoretical neural microtubules to show they can mediate high-efficiency neuroelectrical transmission with quasi-superconductivity.

This study shows how intermittent treatment pulses reshape resource landscapes and spatial growth zones, enabling resistant mutants to escape confinement and drive therapy failure.

This paper introduces phase contrast tomography (PCT) for 3D phase imaging, demonstrating its high resolution and stability for imaging microspheres and sub-organelles.

This study identifies a universal failure in AI models to predict allosteric ligand binding, linking it to biophysical constraints in energy landscapes.

This study shows that neuronal kinesin-1 (KIF5C) forms tetramers through dimer-dimer association, with conformational activation promoting this higher-order assembly.

This study uses molecular dynamics simulations to show that double phosphorylation of MEK1 unwinds its helix, increases solvent exposure of catalytic residues, and induces correlated motion at the active site, enhancing enzymatic activity.