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This study develops a coarse-grained model to investigate how caveolin-1 proteins drive membrane curvature through collective interactions.

This study uses single-molecule FRET to analyze ATP-driven conformational dynamics of TmrAB, revealing hidden intermediates and long ATP-bound states.

This study uses weighted ensemble simulations to assess how molecular glues stabilize protein-protein interactions, showing distinct behaviors that correlate with reported EC50 values.

The paper investigates how mutations in the disordered tail of neurofilament-light protein affect its self-assembled network structure and function, revealing mechanisms linking sequence changes to disease.

This study examines how tensile strain affects cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) from oral squamous cell carcinoma (OSCC) in vitro, finding increased gap closure in CAFs under strain.

This study uses BODIPY-based molecular rotors and FLIM to measure microviscosity in membraneless organelles, revealing differences in viscosity across sub-compartments and changes under perturbation.

The paper shows RNA modulates assembly and activity of two -helical peptides, PSM3 and LL-37, through phase separation and aggregation dynamics, affecting virulence and host defense.

The paper develops a thermodynamic model that unifies phase separation and β-sheet-based aging in intrinsically disordered proteins, validated using nucleoporin-98 variants.

This study measures detachment kinetics of kinesin-1, -2, and -3 under parallel forces using a DNA tensiometer, revealing load-dependent behavior and competition with dynein.

This study investigates Afatinib adsorption on gold nanoparticles using AFM-SEIRA and SERS, revealing molecular interactions and dynamic adsorption behavior.

This study uses all-atom simulations to examine how varying concentrations of lipomannan and lipoarabinomannan affect the structure and dynamics of mycobacterial inner membranes.

This paper investigates how voltage dynamics and ion content in nanoscale compartments differ from larger structures by adapting conductance-based models and simulating small vesicles and macrophage endosomes.

The paper compares Boltzmann distributions of natural and random non-coding RNA, finding natural RNA are slightly more stable, except for short sequences.

The paper uses high-speed AFM and biophysical methods to study dynamic conformational changes in multidomain glycosyltransferases, revealing diverse organizational strategies.

This study shows that protein crowders alter RNA electrostatics and dynamics differently than PEG, challenging the use of PEG as a model for intracellular conditions.

This paper introduces LocScale-2.0 and LocScale-FEM to improve cryo-EM map quality by enhancing local detail while preserving weak structural context and providing confidence scores for interpretation.

This study shows that mycobacterial load and direct contact determine phagosome fate by altering membrane mechanics, leading to spacious or compact phagosomal states that influence bacterial egress.

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

This paper develops a model linking accumulated neurotoxicity from amyloid beta oligomers to biological age, showing that increasing half-lives of Aβ monomers and oligomers accelerates aging.

This study models soil organic carbon in the Andes using machine learning with crop rotation data, finding that fallow frequency is a key predictor of SOC when soil data are excluded.