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This study identifies the molecular mechanism of sodium-dependent fluoride export by FEX proteins using electrophysiology, cryo-EM, and simulations.

The paper reports a cryo-EM structure of cardiac AL-224L amyloid and identifies shared structural features across {lambda}6-LC amyloid folds.

This paper determines the structure of lymphostatin, a multifunctional virulence factor in E. coli, revealing its domains and mechanism of action.

This study identifies non-native amide-π interactions stabilizing a transient intermediate state in amyloid-forming human lysozyme using NMR and MD simulations.

This paper develops a multiscale theory to model mesenchymal cell migration in 2D viscoelastic channels, showing how substrate stiffness and confinement geometry affect migration speed and direction.

The paper presents a structural model of the closed Shaker potassium channel, revealing how voltage sensor movement drives pore opening and identifies a binding site for dalfampridine.

This study uses electron diffraction techniques to determine the structure of in vivo protein nanocrystals from Bacillus thuringiensis, showing they are viable alternatives to X-ray free electron lasers.

This study introduces Growth Mechanics to show that metabolic oscillations in growing cells are necessary for maximizing fitness by optimizing resource allocation.

This study conjugates curcumin with carbon quantum dots (CQDs) to investigate their interaction with BSA, cellular imaging, and intracellular transport using RICS.

The paper develops a mechanistic model to predict CAR T cell killing of tumor cells based on contact dynamics and extracts parameters that determine killing efficiency and tumor resilience.

This study measures EF-G power stroke and its effect on ribosome translocation fidelity using quantum sensing, showing that mutations alter translocation steps and fidelity.

The paper evaluates 53 Pepper RNA variants to show that HBC530 binding affinity and fluorescence intensity are only modestly correlated, with distal structural elements influencing both and Mg2+ binding being strongly correlated with HBC530 binding thermodynamics.

This paper identifies a pH-sensing motif in PagC, an outer membrane protein, that drives bacterial vesicle production and aggregation at acidic pH using in situ NMR and EM.

This study shows that osmotic compression relaxes tissue contractility in different cell types, mediated by RhoA and myosin activity, suggesting a feedback mechanism in morphogenesis.

This study examines how the membrane environment affects enzymatic reactions, finding that it enhances activity but imposes diffusion limitations, which can be mitigated by adjusting enzyme membrane affinity.

The paper shows that a single sugar difference between DNA and RNA drives phase segregation with cationic peptides, enabling programmable synthetic condensates that mimic nuclear compartments.

This study benchmarks RNA 3D structure prediction models using varying accuracy 2D structures, finding that 3D models modify input base-pairing interactions and are more sensitive to false positives in 2D structures.

The paper introduces an anisotropic-isotropic kurtosis mismatch framework using tensor-valued diffusion MRI to characterize stroke lesions in a rat model, finding significant mismatches in key metrics that correlate with pathological findings.

This study identifies how disulfide bond formation during glutenin subunit folding drives the polymerization into linear or branched gluten networks.

This study uses molecular dynamics simulations to show that plasma membrane leaflets have distinct structural and dynamic properties, with the inner leaflet forming nanoscale domains and the outer leaflet being liquid-ordered.