Discover, rate, and discuss biology preprints.

This paper uses machine learning to classify molecular dynamics simulations of viral capsid assembly intermediates, distinguishing between apo and CAM-bound states with high accuracy.

This study shows BRCA1 preferentially binds the open X-like conformation of Holliday junctions and interacts with charged/polar amino acids, many of which are sites of missense mutations.

This paper applies a nonlinear ridge regression method to improve parameter estimation in biexponential signal models for myelin water fraction mapping in the human brain.

This study uses differential dynamic microscopy to analyze cytoplasmic dynamics in Xenopus laevis egg extracts and HeLa cells, revealing subdiffusive motion and cytoskeletal influences on fluidity.

The paper identifies eight small molecules that bind to NPSL2, a regulatory element in oncomiR-1, using virtual screening and experimental validation.

This study creates programmable DNA and RNA liquids that can be tuned by sequence-specific hybridization to control their material properties.

This study shows that a closed-hand posture improves heat retention and blood flow, potentially reducing Raynaud's Phenomenon symptoms through biomechanical and thermodynamic mechanisms.

This study investigates Galectin-1's specificity for GM1 over GD1a in lipid membranes and finds no evidence of cross-linking by homodimers.

The paper proposes a dynamic perspective on homeostasis, suggesting it emerges from multi-dimensional attractors rather than explicit control mechanisms, supported by models and single-cell dataset analysis.

This study shows that single nucleosomes encode A/B compartment information through biophysical properties, specifically condensability, which correlates with gene expression and is electrostatic in nature.

This paper identifies three minimal lipid-only model systems that mimic the lipid composition and mechanical properties of E. coli inner membrane.

The paper develops methods to analyze chromatin condensates using cryo-electron tomography and deep learning, revealing nucleosome structures and interactions in both reconstituted and native systems.

This paper introduces a method using liposome encapsulation to improve cryo-EM structural determination by preserving macromolecules in a near-native environment, reducing disassembly and orientation artifacts.

Flight-Scope enables live-cell imaging of dynamic processes in microgravity using microfluidics during parabolic flights, demonstrated with yeast glucose uptake.

The paper investigates the lipid scrambling activity of Sec61 and TRAP using molecular dynamics simulations, showing they facilitate lipid flip-flop via a credit card mechanism and are selective for phosphatidylcholine.

Cryo-EM at 2.9-3.1 Å shows bacterial OLE, ROOL and GOLLD RNAs self-assemble without protein into a dimer, an 8-chain nanocage and a 14-chain nanocage.

SHINE improves pathway ensemble analysis by integrating n-ary similarity, cheminformatics tools, and hierarchical clustering for MD simulations.

The paper develops a mathematical model to show that delayed ECM feedback limits nascent adhesion growth, matching experimental observations of adhesion dynamics.

This study identifies a dual-site membrane recognition mechanism in ABHD5 that enables its activation and regulation of lipid metabolism.

This study optimizes MR-ARFI for human transcranial focused ultrasound to reduce exposure and improve motion robustness, demonstrating its potential for guiding neural therapeutics.