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This study examines the effects of prenatal oxycodone exposure and melatonin treatment on placental and fetal outcomes in rats, finding that oxycodone impairs fetal growth and placental structure, with partial melatonin mitigation.

The paper uses live imaging to show PRICKLE1 controls neural tube morphogenesis through actomyosin-driven processes independent of planar cell polarity.

DeepHOPE uses deep learning and 3D imaging to assess pluripotency in hPSCs, detecting structural changes before molecular loss of pluripotency.

This study characterizes the cellular and morphogenetic events of sponge metamorphosis, revealing a coordinated program involving epithelial infoldings and cell transitions.

The paper identifies that DNA hydroxymethylation and histone H2B O-GlcNAcylation are both required for zygotic genome activation in mouse zygotes.

The paper shows that paternal folate deficiency affects meiotic chromatin and epigenomic changes in the male germline, particularly at CGI-associated promoters.

The paper shows that defective transcription of AAGAG satellite DNA in Drosophila spermatocytes leads to sex-ratio meiotic drive by causing Y chromosome-containing spermatid death.

This study shows Vgll4 proteins regulate zebrafish organ size by both enhancing and limiting Yap1 activity in the posterior lateral line primordium.

This study identifies Rapgef1b's role in regulating Wnt/β-catenin signaling, affecting early embryonic tissue patterning, morphogenesis, and mitotic fidelity in zebrafish.

This paper introduces a label-free, high-content live-cell imaging pipeline to quantify cell fusion dynamics in real-time, validated using trophoblast syncytialization.

The paper shows Polycomb complexes regulate active chromatin remodeling during ovarian reserve formation and oocyte growth, establishing quiescence and future promoter states through distinct H3K27ac and H3K4me3 dynamics.

DySTrack provides a modular tool for live tracking of dynamic samples on commercial microscopes, enabling integration of image analysis pipelines with vendor software.

This study investigates the functional relationship between Echinoid and Sidekick, two IgCAM proteins, showing they modulate Adherens Junction dynamics and tissue remodelling through bidirectional interactions and shared intracellular adaptors.

The paper shows GATA transcription factors modulate Wnt/β-catenin signaling to control cell identity in the intestinal epithelium by repressing secretory lineage genes in stem cells.

This study differentiates human iPSCs to the syndetome stage using chemically defined media and small molecules informed by single-cell RNA-sequencing, revealing Wnt pathway involvement in off-target neural differentiation and improved syndetome induction with a WNT inhibitor.

The paper shows that ASCL1's ability to induce a neuronal program in pluripotent cells depends on chromatin priming and co-factor availability, with PHOX2B enhancing neuronal differentiation.

This study uses a microfluidic system to investigate mesoderm tissue dynamics and variability in Xenopus embryos, showing that tissue mechanics are governed by cell stiffness and mechanical coupling.

This study shows magnesium and folate reduce dolutegravir toxicity in zebrafish embryos, with magnesium acting through both folate receptor-dependent and -independent mechanisms.

This study shows that RBM8A is essential for bone development and Hedgehog signaling, with its deficiency causing skeletal defects and impaired endochondral ossification.