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This study identifies a specific glycosphingolipid metabolite that modulates Notch signaling in intestinal stem cells, affecting cell fate and tumor formation in both Drosophila and mammals.

The paper identifies a developmentally programmed switch in TCA cycle configuration in Drosophila lymph gland progenitors, showing modular TCA supports progenitor identity and proliferation, while cyclic TCA maintains homeostasis and differentiation.

This paper constructs a single-cell atlas of newt iris cells during lens regeneration, identifying cell types, states, and interactions involved in the IPE-to-LEC reprogramming process.

This study shows that neonatal phlebotomy-induced anemia reduces mitochondrial oxygen consumption and ETC complex function in the hippocampus, impairing energy-demanding neurodevelopmental processes.

This study identifies altered chromatin accessibility in fetal rat hypothalamic neuroprogenitors due to maternal protein restriction, affecting gene regulation and developmental pathways.

This study shows that cilia loss in male germ cells causes centriole clustering and elimination, leading to infertility, while zygotene cilia are not essential for meiotic processes.

The paper shows that defects in nephron progenitor cell differentiation lead to an expansion of Foxd1+ stromal progenitors in mouse models and identifies a conserved subcluster in human fetal kidneys.

The paper identifies CDKN1c/p57kip2 as a regulator of the transition from symmetric proliferative to asymmetric neurogenic divisions in spinal progenitors using single-cell RNA-seq data from chick embryos.

The paper shows NR5A2 uses feed-forward loops with KLF and GATA factors to regulate gene activation during mouse pre-implantation development.

The paper identifies and functionally characterizes a novel cis-regulatory element, apLSE, essential for hindgut morphogenesis and adult survival in Drosophila melanogaster.

This study identifies Lpar1's role in regulating neutrophil retention and epidermal homeostasis in early zebrafish development, showing its impact on inflammation.

This paper uses HiP-CT to analyze the atrioventricular conduction system in ToF specimens, revealing structural anomalies and surgical risks.

This study shows that starvation induces reversible G1/G0 arrest in Vasa2+/Piwi1+ cells of Nematostella vectensis, with refeeding-dependent TOR signaling controlling cell cycle re-entry.

The paper shows that asynchronous polarization in mouse embryos leads to heterogeneity in cell fate specification, linking early 4-cell stage asymmetries to later 8-cell stage lineage decisions.

This paper introduces PT-CLEAR3D, a method for 3D imaging of intact primate testicular tissue, revealing cellular and structural details across three species.

This study investigates FGF signaling's role in caudal regeneration in the annelid Alitta virens, finding it essential for blastema induction but not posteriorization, with conserved mesodermal patterning functions.

This study investigates the role of Tcf21 in zebrafish heart regeneration by knocking out its expression and observing reduced cardiomyocyte dedifferentiation and impaired regeneration.

This study examines transcriptomic changes in the murine duodenum after lethal total body irradiation and NSPP treatment, identifying regenerative gene activation during recovery.

This study shows that glutamine deficiency reduces MPC proliferation by altering TCA cycle enzyme localization and epigenetic modifications, impairing myogenesis.

This study shows that delivering FOXG1 to neurons via AAV vectors improves oligodendrocyte maturation, myelination, and hippocampal structure in mouse models of FOXG1 syndrome.