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The paper examines the gene expression changes in C. elegans mutants with persistent HIF-1 over-activation, revealing shared pathways and functional overlaps with DAF-16 in stress responses.

The paper investigates DNA methylation changes in GCK and TM6SF2 regions associated with metabolic diseases and hepatocellular carcinoma, revealing their impact on G-quadruplex formation and gene regulation.

The paper investigates how host genotype and source environment influence the microbiome of maize, finding genetic variants linked to microbiome composition and environmental adaptation.

The paper creates a humanized knock-in mouse model with a deep-intronic splice-activating variant to test antisense therapeutics for Collagen VI-related muscular dystrophies.

The paper finds stronger polygenic associations with educational attainment in East Germans after reunification compared to West Germans.

The paper quantifies splice-site usage variation across species and identifies intronic hexamer sequences as key determinants of splice-site choice through GWAS and experimental validation.

The paper identifies the epigenetic toolkit of Pristionchus pacificus, revealing the loss of the PRC2 complex and the presence of H3K27me3 through an unknown methyltransferase.

The paper introduces a method to efficiently infer multi-individual identity by descent and detect gene conversion in biobank-scale sequence data, finding over 9 million converted alleles in UK Biobank data.

The paper identifies 28 genomic loci associated with endocranial globularity using imaging genomics data from over 33,000 adults and links them to brain development and other physiological systems.

This study identifies climate-adaptive alleles from Aegilops tauschii that improve wheat performance under drought stress using genome-wide environmental scans and introgression lines.

The paper uses machine learning to predict lifespan and causes of death in aging C. elegans by analyzing senescent pathology and genetic factors.

This study identifies let-7i-5p as a regulator of psoralen-induced osteogenic differentiation of BMSCs by targeting CKIP-1, offering a new therapeutic target for osteoporosis.

This study profiles single-cell multiomic data from clonal hematopoiesis patients and controls, revealing pro-inflammatory profiles in monocytes and T cell dysfunction.

This study examines how estradiol affects gene expression and DNA methylation in the brains of old rhesus macaques after ovariectomy and hormone treatment, identifying molecular networks and gene changes linked to estrogen depletion.

This study shows that mitochondrial stress in GABAergic neurons of C. elegans non-cell-autonomously affects lifespan, stress tolerance, and reproduction.

The paper analyzes population genetics in the Eastern Highlands of Papua New Guinea using genome-wide data, revealing genetic structure, admixture events, and evidence of female-biased migration linked to the kuru epidemic.

This paper introduces two methods to infer demographic history and selection from sequence data by modeling the ancestral recombination graph under the beta coalescent.

This study identifies genetic and molecular mechanisms in Atlantic salmon brains associated with early maturation, linking the Hippo pathway to reproductive timing.

The paper investigates how D4Z4 repeat length and genotoxic stress affect RNA stability and chromatin association of genes at the 4q35 locus.

This study performs a meta-analysis of epigenetic age acceleration across 93 datasets and 23K samples, highlighting geographic, ethnic, and gender differences in aging rates.