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This paper investigates the use of ground germinated barley (GGB) as an oral enzyme replacement therapy (Oral-ERT) for Pompe disease in knockout mice, showing it can reverse enzyme defects and improve clinical phenotypes.

This study investigates the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension, finding no significant difference in liver AGT expression or hypertension phenotypes when the variants occur independently.

This paper investigates the fitness consequences of genetic divergence between polymorphic gene arrangements using analytical and numerical methods, finding that heterokaryotypes have a selective advantage when arrangements are nearly equal in frequency.

The paper uses RNA-sequencing to show that THRA2 is predominantly expressed in human brain development and adult central nervous system tissues.

This study identifies causal genes and transcriptomic factors influencing human telomere length using placental tissue data and GWAS.

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

This study identifies Obp56g as essential for mating plug formation and male fertility in Drosophila melanogaster through functional and evolutionary analyses.

ancIBD identifies IBD segments in ancient DNA to detect relatives and migration patterns, revealing long-distance connections and Steppe ancestry spread in Europe.

This study characterizes NEB mutations in NEM2 patients, revealing mechanisms of nebulin dysfunction and the potential therapeutic benefit of Omecamtiv mecarbil.

The paper identifies recombination hotspots in Neurospora crassa controlled by idiomorphic sequences and meiotic silencing, showing dominant suppression is due to silencing of the active allele.

The paper develops and validates allele-specific RLK gene markers for BBTV resistance in banana, identifying polymorphic markers that distinguish Musa genotypes and reveal genetic diversity.

The paper identifies Avpr1a as a novel candidate gene for chronic visceral pain through genomic and functional analyses in mouse models and human patients.

This paper develops a toolkit for dual control of gene expression in Drosophila using GAL4/UAS and LexA/QF systems, providing new vectors and fly lines for orthogonal gene regulation.

This paper identifies the het-B locus in Podospora anserina, showing that incompatibility is determined by non-allelic interaction between Bh1 and Bp2, with the lectin fold domain of BH dictating specificity.

The paper develops base editing strategies to convert CAG to CAA in Huntington's disease, reducing CAG repeat expansion and showing therapeutic potential.

This study develops a microbiome-enabled genomic selection method that improves prediction accuracy for nitrogen-related traits in maize by integrating host SNPs and rhizobiome ASVs.

The paper identifies an ion transporter gene, nhx-6, as a causative target of RNA binding proteins exc-7 and mbl-1, whose inhibition extends lifespan in C. elegans.

The paper identifies drh-1 as a mechanism to counteract excessive SKN-1 transcriptional activity in C. elegans, improving healthspan by opposing age-related pathology.

This study establishes an HLA-based iPSC banking system for the Saudi population, demonstrating that a small number of iPSC lines can cover a significant portion of the population's HLA haplotypes.

The paper profiles LINE-1 activity at allelic resolution in a single human genome, finding that some LINE-1s are active in vitro but not in vivo, and some old LINE-1s retain activity and may be adaptive.