Discover, rate, and discuss biology preprints.

The paper combines pangenomics and population genetics to identify chromosomal rearrangements, copy number variations, and transposon activity in wheat and rye powdery mildew isolates.

ONTraC uses a graph neural network to analyze spatial transcriptomics data, improving trajectory reconstruction and revealing microenvironment-dependent changes in gene regulation and cell interactions during development.

The paper presents a chromosome-level genome assembly of Bostrychia moritziana, revealing genome size expansion and genetic adaptations in red algae.

eLaRodON improves large genomic rearrangement detection in Oxford Nanopore data, outperforming existing tools with higher accuracy across multiple datasets.

The paper reports the genome of a heat-tolerant and euryhaline cyanobacterium, identifies its genomic features, and compares it to related strains to understand its adaptation mechanisms.

This study presents two high-quality rose genomes and constructs a Rosa pangenome to explore genetic diversity, evolution, and breeding potential in the genus Rosa.

This study shows that cancer-specific activation of retroelements disrupts gene function and tumour-promoting genes, with clinical and experimental evidence supporting these effects.

This study identifies SNPs associated with root system architecture adaptations in sorghum under nitrogen and phosphorus deficiency using GWAS.

The paper develops a duplex PCR assay to determine the sex and mating status of Ixodes scapularis ticks using DNA sequence markers identified through whole-genome resequencing and restriction site-associated DNA sequencing.

This study examines genetic and environmental influences on epigenetic aging variance across adolescence and young adulthood using twin data and four aging estimators.

This study improves genomic prediction of wheat traits by integrating gene expression and environmental data, showing that combining transcriptome and environment data enhances prediction accuracy.

The paper uses GAM to study haplotype-specific 3D chromatin structures in mESCs, finding extensive allelic differences in chromatin architecture and gene expression mediated by Polycomb repression.

The paper measures RNA, protein, and morphology in NSCLC cells treated with TKIs to identify resistance mechanisms and show that CDK4/6 inhibition enhances TKI efficacy.

The paper reports genome expansion in two co-infecting heritable symbionts, attributing it to host-related factors rather than a common mobile element invasion.

The paper identifies genomic alterations in NDV persistently infecting bladder cancer cells that disrupt viral replication and host cell attachment, potentially enabling viral persistence.

The paper introduces Cleopatra, a deep learning model that predicts high-resolution 3D genome maps across human cell types, revealing cell-type-specific loops and gene regulation patterns.

The paper compares CRISPRi perturbation screens and eQTLs in identifying target genes for GWAS-associated loci, finding they often identify distinct genes and complement each other.

This paper introduces a cost-effective DNA extraction method for museum insect specimens, validated against existing protocols and applied to a large sample set.

The paper updates the fungus gnat genome assembly using Hi-C data to produce chromosome-scale scaffolds, improving contig ordering, orientation, and chromosome assignment.

The paper identifies isoswitching, a phenomenon of isoform usage changes in human brain development and aging, and shows it can predict age across the lifespan using RNA-seq data.