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363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- GenomicsbioRxivPreprint
Graph-based pangenome provides insights into the adaptive evolution of Cucurbita pepo
Xuebo Zhao, Kailiang Bo, Honghe Sun…·Zhangjun Fei
The paper constructs a graph-based pangenome of Cucurbita pepo to study adaptive evolution, identifying structural variants and showing parallel domestication and environmental adaptation.
DOI 10.64898/2026.05.27.728270 - GenomicsbioRxivPreprint
The Drosophila melanogaster Genetic Reference Panel, Version 3 (DGRP3)
Richard F. Lyman, Vijay Shankar, Rachel A. Lyman…·Trudy F. C. Mackay
The paper introduces DGRP3, an expanded Drosophila genetic reference panel with 1,233 inbred lines, identifying genetic variants and performing GWAS for traits like inbreeding depression and sensory bristles.
DOI 10.64898/2026.05.29.728783 - GenomicsbioRxivPreprint
Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implications
Salome Jingchen Zhao, Ching Chiek Koh, Rachel Brough…·Serena Nik‐Zainal
The paper shows HRd is a continuum with functional and mutational heterogeneity, highlighting the need for refined molecular classification for precision interventions.
2 citations - GenomicsbioRxivPreprint
Evolutionary Dynamics of Paramecium Mitochondrial Genomes
Ravina S Telkar, Farhan Ali, Samuel F. Miller…·Michael Lynch
This study analyzes mitochondrial genomes of Paramecium to explore evolutionary dynamics, revealing cryptic diversity, conserved genes, and patterns of molecular evolution.
DOI 10.64898/2026.05.26.727735 - GenomicsbioRxivPreprint
Chromosome-level genome assembly of the swallowtail butterfly Parides eurimedes mylotes is a valuable resource for studying wing coloration
Praveen Kumar Jaya Balaji, Tim Davalan, Pamela Nicholson…·Viola Valentina Vogler‐Neuling
The paper presents a chromosome-level genome assembly for Parides eurimedes mylotes, enabling studies on wing coloration genetics and evolutionary biology.
DOI 10.64898/2026.05.27.728091 - GenomicsbioRxivPreprint
OneGenome-Rice (OGR): A genomic foundation model for rice
Bilian Qian, Chengwei Liang, Chao Qin…·Ziqing Deng
OneGenome-Rice (OGR) is a genomic foundation model for rice pre-trained on 422 genomes, outperforming existing models in 11 tasks and enabling downstream applications like trait analysis and gene expression prediction.
- GenomicsbioRxivPreprint
Quantitative metagenomics reveals fine-scale population dynamics across bacteria, archaea, and microbial eukaryotes in an estuarine-coastal continuum
Liang Zhao, Nathaniel P. Curtis, Ryan W. Paerl, Scott Gifford
This study uses quantitative metagenomics to track microbial population dynamics across estuarine and coastal waters, revealing niche partitioning and ecological interactions.
DOI 10.64898/2026.05.28.728481 - GenomicsbioRxivPreprint
Asymmetric population structure in Neoparamoeba perurans and its kinetoplastid symbiont
Brendan Robertson, Bachar A. Cheaib, Konstantin Chekanov…·Kyrie Dickson
The paper analyzes the population structure of Neoparamoeba perurans and its kinetoplastid symbiont Perkinsela, revealing asymmetry in their genetic diversity and transmission patterns.
DOI 10.64898/2026.05.26.727903 - GenomicsbioRxivPreprint
Revisiting CPUs for Protein Folding: Xeon-Based Acceleration of AlphaFold2
Narendra Chaudhary, Wei Yang, Dhiraj D. Kalamkar…·Sanchit Misra
This paper presents an optimized AlphaFold2 implementation for CPUs, achieving significant speedups and higher throughput compared to GPU-based solutions.
DOI 10.64898/2026.05.27.728222 - GenomicsbioRxivPreprint
Life-history traits may buffer genetic erosion under isolation in mountain sky-island systems
Noèmie Collette, Sébastien Pinel, Pascaline Salvado…·Joris A. M. Bertrand
The paper investigates genetic resilience in Xatartia scabra under isolation, finding moderate diversity and low inbreeding despite small population sizes and strong isolation.
DOI 10.64898/2026.05.27.727838 - GenomicsbioRxivPreprint
More than 100 dual coding regions have evidence for selection constraints in both reading frames
Michael L. Tress, Daniel Cerdán-Vélez, Miguel Maquedano, Federico Abascal
The paper identifies 105 dual coding regions under purifying selection in both reading frames, with many linked to brain development and neural functions.
DOI 10.64898/2026.05.28.727796 - GenomicsbioRxivPreprint
Recursive mutational robustness in cancer through intra- and inter-genic compensation
Rohan Dandage, Aldo Hernández-Corchado, Ariel Madrigal…·Hamed Shateri Najafabadi
The paper identifies intra-genic mutational robustness through alternative splicing in cancer, showing it can complement inter-genic robustness and is associated with worse disease outcomes.
DOI 10.64898/2026.05.26.727768 - GenomicsbioRxivPreprint
Draft genome assembly of the Woolly bottlebrush (Greyia radlkoferi) using Pacbio long-read sequencing technology.
Annelin Molotsi, Tracy Madimabi Masebe, Lucky T. Nesengani…·Ntanganedzeni Olivia Mapholi
This paper generates the first draft genome of Greyia radlkoferi using PacBio long-read sequencing, providing insights into its environmental resilience and medicinal properties.
DOI 10.64898/2026.05.26.727846 - GenomicsbioRxivPreprint
Ancient persistence and recurrent emergence of structural variants across divergent Atlantic salmon lineages
Célian Diblasi, Jun Soung Kwak, Domniki Manousi…·Marie Saitou
The paper investigates the evolutionary origins of shared structural variants across Atlantic salmon lineages, finding they result from ancient persistence, recurrent mutation, and lineage-specific frequency changes.
- GenomicsbioRxivPreprint
Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis
Ella Schwab, Leon Chen, Bérénice Anath Benayoun
This study identifies shared and niche-specific transcriptional changes in macrophages across tissues and sexes using a meta-analysis of RNA-sequencing datasets.
DOI 10.64898/2026.02.03.703654 - GenomicsbioRxivPreprint
Development of a microRNA clock for gestational age in the general population
Tim Finke, Midas M. Kuilman, Frédérique White…·Charlotte A. M. Cecil
This paper develops a miRNA-based gestational age clock (miRClock-GA) using cord blood plasma miRNA data and validates it in an independent cohort, showing associations with birthweight and childhood BMI.
DOI 10.64898/2026.05.22.727152 - GenomicsbioRxivPreprint
Atg8 orchestrates stress-responsive chromatin programs across immunity and metabolism
Kevin Kelly, Navyashree A Ramesh, Sunidhi Ranganathan…·Akhila Rajan
This study identifies Atg8/LC3 as a stress-responsive chromatin cofactor that coordinates immune and metabolic transcription through interactions with NF-κB/Dif in Drosophila.
DOI 10.64898/2026.05.22.727304 - GenomicsbioRxivPreprint
Transcription initiation profiling defines the regulatory logic of astrocyte gene regulation
A B Anil Kumar, Yanning Zuo, Numaan Formoli…·Francesca Telese
This study maps transcription initiation in mouse astrocytes to define how inflammatory signals drive cell-type-specific gene regulation and links enhancer activity to human disease risk.
- GenomicsbioRxivPreprint
Shared antimicrobial resistance gene families across gut microbiomes in indigenous Orang Asli communities of Peninsular Malaysia
Li-Fang Yeo, Polly Soo Xi Yap, Aswini Leela Loganathan…·Maude E. Phipps
This study analyzes gut microbiome and resistome diversity in Indigenous Orang Asli communities in Malaysia, finding that urbanization reduces microbial diversity but increases antibiotic resistance gene diversity.
DOI 10.64898/2026.01.29.702475