Discover, rate, and discuss biology preprints.

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

The paper identifies novel cell states and molecular profiles in lupus patients using single-cell data, linking them to disease severity and treatment outcomes.

The paper identifies epithelial cell-state transitions linked to disease severity in pediatric eosinophilic esophagitis using single-cell and bulk transcriptomic data.

This study maps SES-related immune diversity using flow cytometry, finding lower SES associates with downregulated surface proteins and upregulated immune checkpoints.

This study shows IL-17RC signaling in the intestine prevents atherosclerosis by controlling microbiota and perivascular innervation, with loss of IL-17RC increasing inflammation and disease.

This study shows that acute paternal immune activation alters sperm small RNAs, which reprogram embryonic gene expression and enhance offspring survival from viral infection.

The paper identifies Dasatinib as a suppressor of IL-23 signaling in skin inflammation by blocking mTORC1 and mTORC2 activation in γδ17 T cells.

This study compares immune gene expression in ICU and non-ICU Legionnaires' disease patients after LPS stimulation, finding more pronounced functional impairments in ICU patients.

This study identifies HIV-1 Vpr's role in counteracting TASOR to promote infection before integration by inducing TASOR degradation.

The paper identifies coordinated variation between immune systems and microbiomes in healthy humans, linking it to tonic interferon states.

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

This study uses a porcine model to investigate anaphylactoid reactions caused by a carbon-cellulose cartridge, revealing mechanisms of cardiovascular collapse and shock.

This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.

This study shows that gB-targeting antibodies protect neonatal mice from HSV infection, requiring both neutralization and Fc effector functions, with transgenerational protection achievable via AAV-mediated delivery.

This study shows Lyn is essential for B cell anergy by suppressing PI3K signaling in autoreactive B cells, highlighting its role in preventing autoimmunity.

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

This study identifies HIF-1α+ CD4 T cells as key coordinators of a tissue-resident immune network in the lung during infection and cancer.

This study investigates the effects of selective JAK inhibition in AIRE-deficient mice, finding that JAK2 inhibition is most effective in reducing IFN-γ-driven autoimmunity.

The paper develops NanoMAP, a pipeline for analyzing nanobody repertoires, showing it outperforms standard methods in identifying coherent clonal families and detecting high-affinity nanobodies.

This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.