Discover, rate, and discuss biology preprints.

This study identifies neutrophil extracellular traps (NETs) as a contributor to EEHV-HD pathogenesis and demonstrates their inhibition as a potential therapeutic strategy.

This paper reports structural analysis of VRC01-class bnAb precursors from a vaccine trial, showing they bind HIV Env with germline-like features and glycan adaptability.

The gut microbiota enhances translation of innate barrier defense proteins through HDAC5-mediated activation of mTORC1 signaling.

This paper develops circRNA-based in vivo panCAR to achieve comprehensive B cell depletion and reconstitution, showing efficacy in treating B cell disorders and aging in mice and non-human primates.

This study uses dynamic micropatterning to analyze B cell receptor signaling and immune synapse formation, revealing distinct spatial distributions of activated proteins and actin-based protrusion repurposing.

This paper develops a mathematical model of heart-tumour interactions under immune checkpoint inhibitor therapy and uses optimal control to design dosing schedules that balance therapeutic and toxic effects.

This study shows that 2ME2 treatment reduces GVHD mortality and morbidity while maintaining GVL activity in mice.

This study uses spatial transcriptomics to show mitochondrial dysfunction in JDM muscle tissue, independent of interferon-driven inflammation.

This study uses scRNA-seq to analyze immune changes in SIV-infected rhesus macaques over time, revealing immune shifts during infection and ART, and identifying transcriptional signatures linked to immune dysregulation and treatment outcomes.

This study shows that Kabasura Kudineer Choornam modulates human macrophage polarization and phagocytic function by altering marker expression and cytokine secretion.

This study uses scRNA-seq to analyze CSF and blood from TBM patients, identifying inflammatory cell subtypes and altered metabolic pathways in CSF.

This study shows CD24-Fc reduces inflammation and rescues CD8 T cell function in HIV-1 infected individuals on cART.

The paper identifies TR-TEX cells as distinct from TRM cells, showing they have unique transcriptional regulation and respond differently to PD-1 inhibition.

This paper develops a method to predict viral sensitivity to antibodies using genetic sequences and antibody similarities, showing it outperforms existing approaches and can predict neutralization values for unseen viruses.

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

This study identifies LAG3+ CD8+ T cells as key effectors in bispecific antibody armed T cell therapy for HR+/HER2- breast cancer and shows how checkpoint inhibitors can enhance their anti-tumor function.

This study shows that respiratory viral infection primes lung epithelial cells to enhance antigen presentation, leading to improved T cell responses to subsequent antigens.

This study shows that TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni by regulating immune cell responses and limiting parasite dissemination.

This study identifies cytokines that enhance influenza vaccine antibody responses in human organoids and mice, showing their potential as adjuvants to improve vaccine efficacy.

The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.