Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- NeurosciencebioRxivPreprint
Spatiotemporal coordination of specialized cerebellar networks supports episodic memory in older adults
Tengfei Han, Ziyun Li, Chi Zhang…·Zhanjun Zhang
The paper identifies specialized cerebellar networks in older adults and shows that dynamic functional connectivity patterns distinguish memory performance groups, with instability during encoding predicting retrieval slowing.
- NeurosciencebioRxivPreprint
A dynamically coupled kinetic model for Arterial Spin Labeling: Enhancing the reliability of ventricular cerebrospinal fluid renewal quantification in vivo
DOI 10.64898/2026.07.28.741371 - NeurosciencebioRxivPreprint
pH-dependent anti-TfR1 NANOBODY(R) molecules deliver efficacious oligonucleotide payloads to muscle and CNS tissues
Emily A Hoyt, Kristof Moonens, Chiara Rapisarda…·Nina C. Leksa
This study develops anti-TfR1 NANOBODY(R) molecules that deliver siRNA and ASO payloads to muscle and CNS tissues, achieving significant mRNA knockdown.
- NeurosciencebioRxivPreprint
Deep conservation of head direction circuits in bees, ants and flies
Marcel Ethan Sayre, Valentin Gillet, Nils Ceberg…·Stanley Heinze
The paper identifies conserved head direction circuits in bees, ants, and flies, showing stability over 300 million years with evolvable synaptic differences.
DOI 10.64898/2026.07.26.740564 - NeurosciencebioRxivPreprint
Dorsomedial striatal dopamine ramps down during interval timing
Hannah R Stutt, Alexandra S. Bova, Matthew A. Weber…·Nandakumar S. Narayanan
The paper investigates dopamine dynamics in the mouse dorsomedial striatum during interval timing and finds that dopamine ramps down before reward delivery, predicts timing behavior, and varies between sexes and with amphetamine.
DOI 10.64898/2026.08.01.742215 - NeurosciencebioRxivPreprint
Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking
Jacob A. Nadel, Evan S. Swanson, Manhua Zhu…·Talia N. Lerner
This study identifies a novel amygdala-dopamine circuit activated by adolescent stress that drives punishment-resistant reward-seeking behavior in mice.
DOI 10.64898/2026.07.29.741478 - NeurosciencebioRxivPreprint
Computational and causal dissociation in primate striatum during value-guided decision-making
Jiwoo Lee, Min-Seo Kim, Seong-Hwan Hwang, Hyoung F. Kim
The paper shows primate striatal subregions have dissociable, modality-specific roles in value-guided decisions, with neural geometry-behavior coupling determining behavioral control.
DOI 10.64898/2026.07.29.741388 - NeurosciencebioRxivPreprint
ZDHHC17 Links S-Acylation, Huntington Disease, VCP-associated Multisystem Proteinopathy, and Amyotrophic Lateral Sclerosis.
Firyal Ramzan, Gyana Gourab Mishra, Yasmeen Alshehabi…·Dale D. O. Martin
This study identifies ZDHHC17 as a key enzyme linking S-acylation to neurodegenerative diseases by modulating protein localization and toxicity.
- NeurosciencebioRxivPreprint
Hemispheric Fingerprinting: Identifying left and right hemispheres using functional connectivity
Trevor K. M. Day, Peter E. Turkeltaub, Elissa L. Newport, Andrew T. DeMarco
This paper uses supervised learning to classify brain hemispheres as left or right based on functional connectivity, achieving high accuracy in right-handed and left-handed participants.
- NeuroscienceDevelopmental Cognitive NeurosciencePeer-reviewed
The Brain Age Gap as a Predictor of Alcohol Initiation in Adolescence
Hollie R. Byrne, Rachel Visontay, Emma Krogh Devine…·Louise R. Mewton
The paper examines if deviations in brain aging (BrainAGE) predict alcohol initiation and use behavior in adolescents, finding a link with initiation but not with drinking patterns.
- NeuroscienceNeuroimage ReportsPeer-reviewed
Leveraging Pretrained Vision Transformers for classifying Alcohol Use Disorder using Raw Resting-State EEG
Arjun Bingly, Christian Richard, Bernice Porjesz A…·Sivan Kinreich
This study uses EEGViT, a transformer-based model, to classify Alcohol Use Disorder from raw resting-state EEG data, achieving 56% accuracy with sex- and age-stratified results.
DOI 10.1016/j.ynirp.2026.100388 - NeuroscienceHippocampusPeer-reviewed
An update on the model of connectivity of the hippocampal formation (I): the perforant pathway to the dentate gyrus
Jon I. Arellano, PASKO T. RAKIC
The paper updates a model of connectivity from the entorhinal cortex to the dentate gyrus, revealing higher divergence and synaptic complexity than previously described.
DOI 10.1002/hipo.70114 - NeuroscienceNeurocomputingPeer-reviewed
A brain dynamic model based on graph neural network reflect the inter-region interaction of cortical areas
Shaoxian Li, Debin Zeng, Xiaoxi Dong…·Shuyu Li
This paper develops a graph neural network model to predict brain activity and quantify inter-regional interactions, showing it can distinguish Alzheimer's patients from controls.
- NeuroscienceScientific ReportsPeer-reviewed
Nested Contextual change and the temporal compression of episodic memory
Matthew R. Logie, Camille L. Grasso, Virginie van Wassenhove
This study investigates how nested event structures affect memory for temporal and spatial information in a virtual reality setting, finding stronger temporal compression in events with fewer items.
1 citation - NeurosciencebioRxivPreprint
Minocycline engages microglia in the midbrain periaqueductal grey to attenuate hypoxia-triggered panic-like behaviour in rats
Arthur Rocha‐Gomes, Jefferson Manoel Nascimento‐Silva, Beatriz Cassimiro Baratella…·Hélio Zangrossi
This study shows that minocycline reduces panic-like behavior in rats exposed to hypoxia by preventing microglial morphological changes in the midbrain periaqueductal grey.
DOI 10.64898/2026.07.29.741424 - NeurosciencebioRxivPreprint
ENAH Binding to the Huntingtin Proline-Rich Domain Modulates HTT1a Assembly
Jobin Varkey, Anoop Rawat, Priyatama Pandey…·Ali Khoshnan
This study identifies ENAH as an interactor of the HTT1a PRD and shows that EVH1 domain binding modulates HTT1a aggregation and fibril remodeling.
DOI 10.64898/2026.07.29.741051 - NeurosciencebioRxivPreprint
Human brain microRNAs exhibit cell-type specificity and agedependence
Serafima Dubnov, Lihen Laski, Ido Zchut…·Hermona Soreq
The paper profiles microRNA expression in human brain cell types to reveal cell-type specificity and age-related changes.
DOI 10.64898/2026.01.04.697535 - NeuroscienceCell ReportsPeer-reviewed
Hippocampal-cortical coupling dynamics drive system consolidation of remote memory
Tao Sheng, Shaoli Wang, Jiaxi Zhang…·Wei Lu
This study investigates how hippocampal-cortical coupling dynamics during learning and sleep contribute to the system consolidation of remote memory.
DOI 10.1016/j.celrep.2026.117810 - NeurosciencePsychophysiologyPeer-reviewed
Eye tracking insights into movement preparation and execution under nonstandard visual movement feedback
Felix Quirmbach, Jens R. Helmert, Sebastian Pannasch…·Jakub Limanowski
This study investigates oculomotor correlates of hand-eye coordination under standard and nonstandard visual feedback, finding increased pupil dilation and reduced tracking performance during expectation violations.