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The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

This study shows that periostin exon 17 skipping combined with AAV-microdystrophin improves muscle function and microdystrophin expression in a fibrotic DMD model.

This study identifies early proteasome dysfunction and transcriptional downregulation in Alzheimer's disease, contributing to proteostasis failure and neurodegeneration.

This study uses untargeted metabolomics to analyze metabolic changes in the hearts of hypothyroid mice, revealing disruptions in lipid and carbohydrate metabolism.

This study investigates misophonia's relationship with affective flexibility, cognitive flexibility, and rumination, finding inverse associations between misophonia severity and both flexibility measures, and a positive link between rumination and misophonia severity.

This paper validates cardiovascular magnetic resonance (CMR) methods for detecting myocardial fibrosis in mini-swine against histology, finding that T1-mapping outperforms LGE for low-grade fibrosis.

CLOVER integrates multi-omics data with whole-slide images to generate molecular-aware slide representations, outperforming existing methods in cancer subtype classification and biomarker prediction.

This study shows that impaired liver lymphatic function drives fibrosis and cirrhosis progression and identifies VEGF-C as a potential therapeutic target.

This paper establishes a novel murine tail irradiation model to study radiation-induced skin injury, finding dose-dependent fibrosis and dynamic melanin changes.

This study identifies Loxl2 as a therapeutic target for LMNA cardiomyopathy by showing its role in ECM remodeling in patient-derived cardiomyocytes and mouse models.

This study develops a preclinical chronic wound model using snake venoms to characterize venom-induced wound pathophysiology and identify unique features.

PixlMap is a deep learning method for cellular phenotyping in multiplex immunofluorescence images that uses nuclear segmentation alone to classify cells without requiring full cell boundaries.

The paper analyzes cervicovaginal specimens to show that Lactobacillus species, particularly L. crispatus, protect against HPV infections, bacterial vaginosis, and epithelial abnormalities.

This paper develops a humanized mouse model of V122I ATTR-CM and identifies inflammatory pathways involved in its pathogenesis.

This study shows malonate prevents chemotherapy-induced cardiotoxicity by inhibiting mitochondrial reverse electron transport, preserves cardiac function, and sensitizes AML cells to intensive chemotherapy.

This paper identifies thymus-origin pre-B lymphomas in SL/Kh mice and links them to human mediastinal large B-cell lymphoma through Notch1 signaling and retroviral mutagenesis.

This paper optimizes immunohistochemical protocols for assessing the enteric nervous system in formalin-fixed human tissue using multiple protein markers.

This study identifies pro-regenerative features in TSP2-deficient fibroblasts through single-cell analysis and functional assays, showing enhanced migration, proliferation, and neurogenesis.

This study investigates the interaction between osteoprotegerin and fibulin-1 in lung fibrosis, finding they form a complex with fibulin-1 bridging OPG and LTBP1, influencing extracellular matrix deposition.

This study investigates sex-specific differences in periodontitis progression, finding that neutrophil inflammation drives sexual dimorphism in bone loss.