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This study investigates the mechanisms controlling hemolymph circulation during resting conditions in Rhodnius prolixus, identifying a role for Piezo proteins and other signaling pathways.

This study shows that inhibiting DPP-4 and NEP in mice improves the detection of intact GLP-1 using commercial ELISA kits, but may affect metabolic outcomes.

This study shows that a high-fat and fructose diet in dogs causes insulin resistance and β-cell dysfunction similar to human impaired glucose tolerance and type 2 diabetes.

This study investigates the role of endothelial cell SGK1 in vascular stiffening, finding that its inhibition reduces stiffness in both mouse models and human endothelial cells.

This study examines how two species of weakly electric fish adjust their electric organ discharge amplitude and metabolic rate in response to increased water conductivity.

This study shows that frataxin deficiency in microglia shifts metabolism to glucose catabolism, causing inflammation, which is mitigated by butyrate treatment.

The paper identifies exceptionally long-lived macromolecules in mammalian ovaries and oocytes that contribute to reproductive health across the lifespan.

This study shows that NFAT5 in endothelial cells limits hypoxia-induced maladaptive remodeling of pulmonary arterioles by restricting HIF1-mediated Pdgfb expression.

This study shows that S6K1 deletion reduces inflammation and immune infiltration in aged livers, suggesting it suppresses the inflammatory SASP, contributing to healthspan benefits.

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

This study compares molecular adaptations in inguinal white adipose tissue from exercise-trained and cold-exposed mice, showing distinct proteomic and secretomic changes that affect systemic glucose metabolism.

This study shows that post-surgical opioid use and surgery itself impair airway protection in cats, increasing aspiration pneumonia risk.

This study compares the effects of semi-synthetic and grain-based diets on breeding outcomes and metabolic health in adult C57BL/6J mice, finding diet type influences body composition, fecal microbiota, and reproductive success.

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

This study shows that hemodynamic perturbations and endothelial injury form a cycle driving pulmonary arterial hypertension, which can be reversed by unilateral lung banding.

This study compares ion fluxes and osmolarity changes in three grass species under salt stress, finding differences in their salt tolerance mechanisms.

This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.

This study shows that intermittent glucocorticoid treatment rescues both energy and mass in aging-related sarcopenia via the PGC1alpha-Lipin1 pathway in muscle cells.

This study shows that improving systemic insulin sensitivity via hepatic FoxO deletion does not reduce atherosclerosis in mice and may even increase it.