Discover, rate, and discuss biology preprints.

This study shows elevated plasma cholesterol improves sepsis survival by promoting hepatic metabolic reprogramming, as demonstrated in both human patients and mouse models.

This study shows that increased action potential duration variability and calcium sparks precede early afterdepolarisations in ventricular myocytes, suggesting calcium handling instability as a key mechanism for drug-induced arrhythmias.

This study shows that dietary cholesterol and saturated fat together drive fibrosing MASH via gut microbiota changes, specifically increasing Parasutterella spp. and activating hepatic stellate cells.

This study shows that deleting BAG3 in endothelial cells uniquely alters the proteome of specific organs, with the most significant changes in skeletal muscle.

This paper uses a neural network to rapidly calibrate a cardiovascular ODE model for virtual twin generation, showing it can achieve accurate results while being computationally efficient.

This study shows that ZIP9 deficiency in zebrafish disrupts zinc distribution, reproductive endocrinology, and female fertility.

This study shows imatinib lowers right ventricular systolic pressure without affecting vascular remodeling in a mouse model of pulmonary hypertension.

The paper shows that aminoglycosides accumulate in the tectorial membrane, and its structural integrity affects ototoxicity.

This study identifies the vocal mechanism of the singing mouse, revealing that its whistle-like song relies on air sac inflation and specific laryngeal muscles for frequency control.

The paper tests if inactive muscle mass imposes an inertial penalty on work during submaximal contractions in rat plantaris muscles, finding no significant reduction in work beyond that explained by decreased fascicle strain.

This study evaluates TRPC6 missense variants in cancer patients using molecular docking and patch clamp electrophysiology to predict functional impact and guide clinical decisions.

This study reviews and analyzes 20 studies on mitochondrial function in older adults using 31P-MRS, finding no overall decline in {tau}PCr but muscle-specific differences.

This study uses computational modeling of foot-ground force data to identify distinct balance control strategies in post-stroke individuals compared to unimpaired adults.

This study shows that ovarian failure or removal increases atherosclerosis but does not impair limb recovery in a mouse model of peripheral artery disease.

This study shows that loss of PROX1 in adult mouse Schlemm's canal leads to permanent ocular hypertension by converting the canal to a vein-like phenotype.

This paper compares methods for estimating mouse total body surface area (TBSA) and finds that stretching the pelt inflates TBSA measurements, while relaxed pelt or dorsal-ventral tracing provides more accurate estimates.

This study investigates the role of hepatic HIF2α in MASLD, finding that its deletion leads to extra-hepatic complications like cardiac dysfunction and lean mass loss without protecting against liver disease progression.

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

This study uses in vivo two-photon imaging to show that cholinergic axonal Ca2+ signals correlate with arteriolar dilation in mice.

The paper studies how different mechanoreceptor afferents encode multiple aspects of touch during sliding contact, showing that FA-1 afferents respond to force, velocity, and spatial period, while SA-1 afferents mainly respond to force.