Discover, rate, and discuss biology preprints.

This study validates body condition scoring (BCS) as a screening tool for low body condition and obesity in common marmosets using quantitative magnetic resonance (QMR) as a reference.

This paper shows that the gap between elite female and male runners has continued to shrink since 2001 across all distances, contrary to the belief that it stabilized in the late 20th century.

This study compares cytokine responses in male and female mice to TFEB overexpression and voluntary wheel running, revealing sex-based differences in exercise-induced inflammation.

This study measures mechanical work and metabolic cost of locomotion in elephants, revealing size-dependent patterns and efficiency similar to other large mammals.

This study links pupil responses to social stimuli with adaptive behaviors in infants aged 6-24 months using SESAMI and pupillometry.

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

This study shows that maternal obesity alters FOXO1 activation and adipogenesis in neonatal mesenchymal stem cells, leading to increased adipogenic potential.

This study shows that Anxa6-/- mice have impaired fasting-induced hepatic gluconeogenesis, leading to hypoglycaemia and reliance on lipid oxidation.

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

This study examines how diclofenac and eugenol modulate Kv7 and TRPV1 ion channels, showing enhanced analgesic effects when combined in animal models.

This study investigates how carbamazepine (CBZ) affects thalamic reticular neurons, revealing it selectively inhibits their tonic firing and disrupts GABAergic transmission, which exacerbates absence seizures.

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.

This paper introduces a frequency-domain framework for cardiovascular power distribution, modeling the heart as a multi-frequency power source and organs as frequency-tuned loads, with simulation results supporting its physiological and clinical relevance.

This study shows that Siglec-F deficiency reduces fibrosis in bleomycin-induced lung injury by altering gene expression in airspace macrophages.

This review evaluates guinea pig models of maternal stress during pregnancy, finding significant fetal effects but limited understanding of maternal physiological adaptations.

This study examines DNA methylation changes in crucian carp brains during anoxia and reoxygenation, identifying differentially methylated regions and their association with gene expression.

This study shows that mice adjust their behavior and metabolism in response to protein restriction, with temperature affecting amino acid homeostasis and metabolic adaptations.

This study uses a novel preparation to visualize and quantify cardiac pericytes under physiological conditions, revealing their extensive organization and potential roles in signaling and contractile support.

This study compares drought responses between isohydric and anisohydric tree species, finding isohydric species experience earlier declines in stem water content, sap flow, and growth than anisohydric species during soil dry-down.

This study shows that gut microbes regulate glomerular filtration rate (GFR) in mice, with their suppression increasing GFR in both healthy and chronic kidney disease models.