Discover, rate, and discuss biology preprints.

The paper identifies Pho4-Pho84 as a conserved mechanism for maintaining intracellular phosphate homeostasis in yeast under phosphate-replete conditions.

The paper shows how spatial structure in the gut microbiota emerges through bacterial growth in the matrix of gut content.

This paper compares predictive models for rat plasma concentration-time profiles, finding that physics-informed neural networks outperform other methods, especially with limited data.

The paper introduces a parametric failure-based model to quantify and compare cell-state transition kinetics across conditions, showing it captures delay, timescale, hazard form, and response fraction.

This paper develops a large language model-based method to extract metabolic engineering strategies from research articles and trains a hybrid model to predict engineering targets, outperforming traditional approaches.

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

The paper develops a spatially explicit model of in vitro viral infection with DIPs, showing how they affect IFN response and plaque morphology.

The paper investigates how BMP and TGFβ pathways interact asymmetrically, showing that TGFβ inhibits BMP and BMP enhances TGFβ responses, reducing signaling ambiguity.

The paper develops a cell-type-resolved metabolic flux inference pipeline to analyze human cardiomyopathies, revealing stromal metabolic reprogramming and genotype-specific metabolic alterations.

The paper develops an agent-based model to predict neural stem cell migration in mouse brains using multi-fiber tractography, showing injection location affects distribution and suggesting factors like chemotaxis may be important.

The paper investigates water-mediated interactions in coral reef communities, finding that these interactions can alter ecosystem productivity and functioning during phase shifts, independent of physical competition.

The paper develops a mathematical model of RAF activation modulated by 14-3-3 proteins, showing that weak binding stabilized by avidity explains experimental observations of RAF activation upon 14-3-3 overexpression.

The paper predicts patient-specific metabolite secretion patterns in Parkinson's disease using a novel algorithm, identifies subgroups based on these patterns, and validates the findings with independent data.

The paper investigates crosstalk between splicing factors and kinase networks using phosphoproteomics and RNA-seq data, showing significant changes in phosphorylation and kinase activity upon splicing factor knockdown.

The paper identifies age-related molecular changes in mouse spleens using proteomics and transcriptomics, showing cell-type-specific remodeling and gender differences in post-transcriptional buffering.

This study examines how wind-driven hydrodynamics affect coral fertilization and larval development, finding that increased wind speeds reduce fertilization success and embryo viability.

This study uses spatial transcriptomics to map subcellular mRNA localization across tissues, revealing conserved and tissue-specific patterns.

The paper identifies conserved metabolic vulnerabilities across SARS-CoV, SARS-CoV-2, and MERS-CoV using transcriptomic data and metabolic models, revealing druggable host targets.

The paper analyzes attractor coherence in Boolean gene regulatory networks, revealing that attractors representing mature cell types are less stable than their basins due to canalization.

SugarBase identifies microbial nucleotide sugar profiles, revealing species-specific and previously unannotated sugars, and expands antimicrobial targets.