Discover, rate, and discuss biology preprints.

This study characterizes the pharmacokinetic properties of ent-verticilide, identifying limited intestinal availability and CYP-mediated metabolism as key factors affecting its oral exposure.

This study shows that high SETDB1 protein expression in bladder cancer is linked to shorter overall survival and specific tumor features.

The paper identifies shared genetic variants between hypertension and preeclampsia that regulate immune-related genes, linking gene expression to blood pressure traits and clinical phenotypes.

This study quantifies how environmental factors and frequency affect signal detection in Passive Acoustic Monitoring using playback experiments in a tropical agroecosystem.

This study shows that NK cell TGF-β signaling regulates postnatal lung development and BPD by affecting vascular patterning and senolytic activity.

CRISPR-dPCR quantifies CRISPR knock-in by distinguishing integration from donor abundance and background, using multiplex digital PCR with orthogonal strategies.

The paper investigates how spatial and transcriptional dynamics at Cd4 and Cd8 loci influence T cell lineage choice in the thymus, revealing locus-specific chromatin environments that drive differentiation.

The paper uses network analysis, MD simulations, and experiments to identify critical residues in human PrP that affect structural stability and misfolding.

This study investigates the oligomerization and activation mechanism of the RPS4-RRS1 immune receptor complex in Arabidopsis, showing that effector recognition triggers conformational changes that enable NADase activity.

This paper develops a pharmacologically controlled system for regulating CAR T cell function using estrogen receptor-based degron domains and FDA-approved compounds.

The paper develops GPCRmd-NMR, an integrative platform combining MD simulations and NMR spectroscopy to analyze GPCR dynamics at unprecedented scale.

This study reveals the unliganded active state of the β2-adrenergic receptor using pressure-resolved DEER and ProGuide modeling, showing pressure-dependent conformational changes and allosteric coupling.

This study compares the colonization patterns of Pseudomonas chlororaphis M71 and Trichoderma atroviride SC1 in grapevine after stem injection, showing distinct movement and persistence behaviors.

This study evaluates the effectiveness of combining Azospirillum brasilense with cytidine or seedling exudate to improve pea drought resilience, finding that cytidine enhances drought tolerance and rhizosphere diversity.

The paper integrates ATAC-seq and RNA-seq data from zebrafish osteoblasts to identify chromatin and transcriptomic signatures and mechanisms of entpd5a regulation.

The paper investigates how input encoding and spike detection methods affect neural representations and reservoir computing performance in biological neural networks for multiclass time-series classification.

The paper shows that GABAB receptor activation in SST interneurons leads to PP2A-dependent internalization, affecting plasticity and disrupting contextual memory.

The paper uses CRISPR-LICHT to screen SOX2 targets in human brain organoids, identifying 28 new genes involved in neural progenitor lineage expansion and survival.

The paper identifies brain-specific functions of NDD-associated genes by analyzing gene expression and regulatory mechanisms across tissues.

The paper introduces CSDE, a method that improves differential expression analysis in spatial transcriptomics by incorporating expert feedback to mitigate preprocessing biases.