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This study shows that rotavirus NSP1 activates the NLRP1 inflammasome through proteasomal degradation, independent of double-stranded RNA.

The paper systematically adjudicates genetic evidence for Alzheimer's disease and related dementias, identifying 111 high-confidence loci through a tiered framework applied to large-scale genome-wide studies.

This paper uses large language models to analyze 2.4 million bibliographic records and identifies gaps in research attention to biodiversity loss across different ecological contexts.

This paper develops an HNSCC-on-a-chip model with tunable engineered extracellular matrices, vasculature, and innervation to study tumor behavior and therapeutic responses.

This study evaluates how sex, age, and mouse strain affect M. abscessus infection progression using a beads model, finding BALB/cJRJ mice show more sustained infection with less variability.

This paper introduces a competitive transplantation method using HLA-mismatched human hematopoietic stem cells in humanized mice to study repopulating capacity and track graft dynamics.

This study identifies FXR2 as a mediator of autophagy that clears Sindbis virus capsid and protects against viral encephalitis by reducing viral protein toxicity.

This study compares spindle behavior in C. elegans and C. inopinata embryos, finding differences in pronuclear migration and spindle oscillations linked to changes in cortical force generation.

CellCompass, an agentic AI system, models cell dynamics from single-cell measurements and improves predictions by integrating new biological constraints and experimental data.

This paper evaluates how unified perturbational modeling improves AI virtual cell predictors by integrating heterogeneous Perturb-seq datasets and achieving better performance across benchmarks.

AltereGO fuses protein language models and structure representations to predict molecular functions, achieving better performance than individual models and some existing methods.

The paper develops a framework using SE(3) manifolds to model 3D spatial representations in neural systems across species.

This study identifies CAMKK2 as a key driver of kinase signaling in gastric cancer through phosphoproteomic analysis, showing its role in promoting proliferation and malignant traits.

This paper uses serum protein profiling to identify aging trajectories and strain-specific resilience in mice, revealing pathway-level changes and heterogeneity between strains.

The paper identifies a novel gene, beer belly, as a regulator of segmentation in spiders using single-cell RNA sequencing and shows its evolutionary loss in mammals and holometabolous insects.

The paper shows that respiration-deficient cells rely on pyruvate carboxylase to prevent asparagine auxotrophy, with effects dependent on mitochondrial heteroplasmy levels.

This paper evaluates how different evaluation designs affect cross-donor generalization in single-cell classification, finding that random cell-level splitting overestimates performance compared to donor-held-out evaluation.

This study identifies DHX30 as an R-loop helicase that resolves RNA:DNA hybrids, prevents replication stress, and maintains genome stability in human and zebrafish cells.

This study investigates how PSK and BR receptors dynamically reorganize at the nanoscale to differentially affect cell wall properties during plant growth.