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The paper develops a k-segment constrained HMM for LOH detection in sparse single-cell WGS data, achieving high recall and precision.

This study uses OCT to show that the anatomical integrity of the organ of Corti affects cochlear structural motion in human cadaveric specimens.

This study identifies the neural circuitry regulating feeding-fasting rhythms in Drosophila larvae, showing that s-LNv and SIFa neuron interactions are critical for rhythm development.

biHash is a rolling hash algorithm designed for bisulfite-sequenced data, offering faster hashing by recognizing bisulfite-compatible sequence states.

This study shows that simvastatin reduces clozapine-induced lifespan extension and mitochondrial recovery in Drosophila, suggesting a trade-off between mitochondrial adaptation and health outcomes.

This study shows maternal e-cigarette vaping increases AAA growth in offspring mice and causes transgenerational DNA methylation and accessibility changes.

The paper uses spatial transcriptomics to analyze molecular differences in mood disorders and biological sex in the human prefrontal cortex, identifying sex- and disorder-specific gene expression patterns.

Camus is a video-based system for continuous behavioral monitoring in mouse home cages, capturing circadian patterns and behavioral deficits in transgenic mice.

This study shows that 7SK-snRNP components HEXIM1 and LARP7 promote replication fork reversal and homologous recombination under transcription and replication stress, independent of BRCA1.

The paper identifies a polysynaptic hypothalamus-pelvic-ganglion circuit that promotes prostate tumor growth through WNT3A signaling in mice.

The paper introduces mobileRNA, an R package that efficiently identifies mobile RNA molecules in grafted plants using merged genome alignment and simulated datasets.

This study examines how cerebral blood flow responds to motor activation during breath-holding, finding reduced but still detectable perfusion increases in motor areas compared to normal breathing.

This study benchmarks uncertainty estimation in virtual spatial transcriptomics, finding that predicted means largely explain prediction error, and uncertainty provides limited additional information.

This study demonstrates that deep PrP lowering with a potent siRNA prevents prion disease symptoms in mice and extends survival in symptomatic animals.

This paper introduces multi-peptide example prompts (MPEPs) to enable in-context learning in protein language models for peptide classification without training.

This paper demonstrates single-molecule nanopore sensing using a solid polymer electrolyte instead of liquid electrolytes, enhancing sensitivity and enabling robust, portable sensing platforms.

The paper develops a halide-sensitive YFP quenching assay to functionally validate BEST1 variants and distinguish loss-of-function from gain-of-function mutations.

RNASTOP predicts and optimizes mRNA chemical stability using deep learning, improving accuracy by 13% and reducing free energy in a vaccine sequence.

The paper shows aldosterone enhances synaptic transmission in HSD2 neurons through SV2C, driving sodium appetite.

The paper identifies subterminal heterochromatin in tetrapods using k-mer distributions, revealing ancient subgenome-specific repeats in Xenopus laevis.