Discover, rate, and discuss biology preprints.

This study uses a Transformer-based model to predict astrocyte migration during mouse brain development, finding that environmental information and multimodal modeling improve prediction accuracy.

The paper determines the structure of the PDZ-RhoGEF catalytic core-RhoA complex and identifies an allosteric mechanism by which the GEF switch enhances activity.

This study investigates how 16p11.2 copy number variations affect white matter structure by analyzing axonal and myelin volume and g-ratio across different cohorts.

This study shows that acute SMARCA4 loss in ARMS cells does not induce differentiation or alter proliferation, contrasting with long-term knockdown effects.

BiNVaST improves cell typing across spatial transcriptomic platforms by generating synthetic data that preserves niche boundaries and integrates molecular and spatial information.

The paper analyzes eccDNA length distributions and breakpoint organization across multiple datasets to show that eccDNA formation is influenced by nucleosome positioning and DNA helix orientation.

This study shows how environmental factors like nutrients, pH, and oxygen affect the evolution of antibiotic resistance in Pseudomonas aeruginosa.

This study shows that a few genes, not genome-wide diversity, drive ecological impacts of a freshwater fish on food webs and ecosystem functions.

This paper introduces digital flow cytometry assays for high-throughput, quantitative affinity measurements of antibodies against both soluble and membrane targets.

This study identifies tissue-specific proteomic changes in a Drosophila SCA17 model, showing polyglutamine-expanded TBP affects pathways beyond transcription.

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

This study shows that microbiomes, not plant size, more strongly influence flowering and growth in milkweed, with leaf microbiomes predicting growth and soil microbiomes predicting flowering.

This study identifies de novo structural variants in individuals with orofacial clefts and finds they contribute to genetic risk, with some variants disrupting known risk genes and suggesting new candidate genes.

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

This study develops a new cultivation method for Blastocystis, revealing that multiple strains can coexist within a single host.

This study investigates the roles of two β-CAs in tomato, finding that SlβCA4 is critical for growth, carbon assimilation, and temperature-responsive stomatal plasticity, while SlβCA1 has less impact.

The paper demonstrates that modified 3rd-generation SMEF (3m-SMEF) protects against ischemia-reperfusion-induced AKI by preserving Na/K-ATPase function and tubular integrity in vitro and in vivo.

This study identifies 18 chromosomal inversions in Littorina saxatilis that respond to environmental variation and influence phenotypic traits, explaining 15% of phenotypic variation.

CnidoSite provides a centralized multi-omics database for cnidarians, integrating genomic, transcriptomic, proteomic, and phenotypic data to study thermal tolerance and environmental adaptation.

The paper develops a general mathematical model of symport based on conformational transitions, showing it fits experimental data from multiple transporter families and reveals mechanistic principles.