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GLnexus, a joint variant caller backed by an incrementally growable gVCF database, largely matched GATK on 50,000 exomes while keeping more rare indels and using 3.8–6.6-fold fewer core-hours.

Cas9-induced double-strand breaks trigger p53/p21/RB1-dependent G1 arrest in RPE-1 cells; transient p53 inhibition via MDM2 markedly raises homologous recombination precision editing efficiency.

FASTmrMLM swaps mrMLM's numerical gradients and Hessians for analytic ones, cutting runtime by more than 50% while matching or slightly beating its simulated power and accuracy.

The lncRNA Cyrano drives multiple-turnover degradation of miR-7 in mouse brain, which protects the circRNA Cdr1as from miR-7-dependent, partly miR-671-sliced destruction.

MOFA, a sparse Bayesian factor model with mixed likelihoods, separates shared from modality-specific multi-omic variation, recovering IGHV, trisomy 12 and oxidative-stress axes in 200 leukaemia samples.

Linear decoding followed by a convolutional autoencoder reconstructs natural images from 5398 simulated macaque retinal ganglion cell responses better than linear decoding (test mean squared error 0.0051 vs 0.0077).

Encoding imputed genotype probabilities at 8 bits in BGEN gave compact files, ~240 million probabilities parsed per second and association results near-identical to 20-bit data (UK BiLEVE chromosome 22).

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.

MR-PRESSO detects pleiotropic outlier instruments in summary-level Mendelian randomization; across 82 traits it found pleiotropy in 41% of significant causal estimates, with distortions from −168% to 189%.

A yeast-based refactoring platform (HEx) with new inducible promoters, an engineered host strain, and homology-based assembly expressed 41 cryptic fungal gene clusters; 22 yielded non-native compounds.

ampvis2 unifies 16S amplicon count tables, taxonomy, and sample metadata in one R object, feeding ggplot2 heatmaps at any taxonomic rank and single-call ordination (seven methods).

Aggregating UMI counts from a cell's nearest neighbours, chosen step-wise on variance-stabilised profiles, cuts technical noise enough that PCA and hierarchical clustering resolve cell types and T cell subsets.

Seurat combines canonical correlation analysis and dynamic time warping to co-embed scRNA-seq datasets from different conditions, platforms, or species, outscoring ComBat and limma in alignment score.

Deep learning rivals or beats baselines across imaging, health records, genomics and drug discovery but is not yet transformative; scarce labels, privacy and opacity remain hurdles.

An average-pairwise Tanimoto internal diversity metric shows reinforcement learning and ORGAN generators lose diversity among desired molecules, ending far below reference-set diversity.

NanoPack bundles Python3 tools (command line, GUI, web service) for QC plotting, summary statistics, read filtering and contaminant removal of Oxford Nanopore and PacBio long reads.

Open source off-lattice agent-based C++ simulator PhysiCell, coupled to the BioFVM diffusion solver, simulates 3-D multicellular tissues with cost linear in cell number, reaching roughly 10^6 cells.

Ancient DNA from 223 people (12,000-500 BCE) reveals a west-east hunter-gatherer cline, largely unadmixed farmers, Caucasus-shifted Aegean farmers, and Balkan steppe ancestry almost 2,000 years early.

Python toolkit Scanpy, built on HDF5-backed AnnData, achieves speedups of 5 to 16 times over Cell Ranger's R kit and clusters 1.3 million cells without subsampling.