Author

P. A. Rice

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

X.-H. Su· 5 shared C. A. Genco· 4 shared W.-J. Le· 3 shared X. Li· 3 shared X. Lou· 3 shared K. Lolans· 2 shared A. Ansari· 1 shared A. Arra· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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5 shared papersMicrobiology

X.-H. Su

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence.

N. T. Q. Nhu, H. Lin, Y. Pigli, J. K. Sia, P. Kuhn, E. S. Snitkin, V. B. Young, M. Kamboj, E. G. Pamer, P. A. Rice, A. Shen, Q. Dong

The paper identifies that longer inverted repeats in the flagellar switch region of C. difficile RT027 strains correlate with greater virulence and phenotypic heterogeneity in flagellar gene expression.

bioRxiv · Jun 22, 2023 · PreprintMicrobiology

A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut

E. C. Fogarty, M. S. Schechter, K. Lolans, M. L. Sheahan, I. Veseli, R. Moore, E. Kiefl, T. Moody, P. A. Rice, M. K. Yu, M. Mimee, E. B. Chang, S. L. McLellan, A. D. Willis, L. E. Comstock, A. M. Eren

The paper identifies a highly prevalent cryptic plasmid in the human gut that is more numerous than crAssphage and has potential applications in detecting fecal contamination and inflammatory states.

bioRxiv · Mar 25, 2023 · PreprintMicrobiology

Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

M. Zhang, M. Kennedy, O. DeLeon, J. Bissell, F. Trigodet, K. Lolans, S. Temelkova, K. T. Carroll, A. Fiebig, A. M. Deutschbauer, A. M. Sidebottom, C. S. Henry, P. A. Rice, J. Bergelson, E. Chang

This study tracks genetic and metabolic changes in Bacteroides thetaiotaomicron during gut colonization, showing shifting gene usage and highlighting the importance of carbohydrate metabolism for long-term persistence.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

In vitro activity of ertapenem against Neisseria gonorrhoeae clinical isolates with decreased susceptibility or resistance to extended spectrum cephalosporins in Nanjing, China (2013-2019)

X.-H. Su, X. Li, W.-J. Le, X. Lou, C. A. Genco, P. A. Rice

The paper examines ertapenem susceptibility in Neisseria gonorrhoeae isolates from Nanjing, China, showing increasing resistance over time and associations with specific genetic markers.

bioRxiv · Jan 25, 2022Microbiology

Structural basis for topological regulation of Tn3 resolvase

S. P. Montano, S.-J. Rowland, J. R. Fuller, M. E. Burke, A. I. MacDonald, M. R. Boocock, W. M. Stark, P. A. Rice

This study presents structural and biochemical data to propose a new model of the Tn3 synaptosome and how it uses DNA topology to regulate recombinase activity.

bioRxiv · Dec 7, 2021Biochemistry

In vitro efficacy of gentamicin against multidrug-resistant Neisseria gonorrhoeae: synergy of three gentamicin antimicrobial combinations

X. Li, W.-J. Le, X. Lou, B.-w. Wang, C. A. Genco, P. A. Rice, X.-H. Su

This study evaluates the in vitro efficacy of gentamicin alone and in combination with three antibiotics against multidrug-resistant Neisseria gonorrhoeae, finding synergistic effects in some combinations.

bioRxiv · Apr 26, 2021 · PreprintMicrobiology

Susceptibility trends of zoliflodacin against multidrug-resistant Neisseria gonorrhoeae clinical isolates in NanJing, China (2014-2018)

W.-J. Le, X.-H. Su, X. Lou, X. Li, X. Gong, B.-X. Wang, C. A. Genco, J. P. Mueller, P. A. Rice

This study tracks zoliflodacin susceptibility trends in Neisseria gonorrhoeae isolates from 2014-2018, showing increasing MICs and resistance mutations, while maintaining overall susceptibility.

bioRxiv · May 4, 2020Microbiology

Static kinks or flexible hinges: conformational distributions of bent DNA bound to integration host factor mapped by fluorescence lifetime measurements

M. Connolly, A. Arra, V. Zvoda, P. J. Steinbach, P. A. Rice, A. Ansari

This study uses fluorescence lifetime measurements to show that IHF-DNA complexes exhibit conformational flexibility, with some DNA remaining unbent or partially bent despite IHF-induced kinking.

bioRxiv · Aug 2, 2018Biophysics

Transcriptome Analysis of Neisseria gonorrhoeae During Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants Between Men and Women

K. Nudel, R. McClure, M. Moreau, A. J. Abrams, B. Tjaden, X.-H. Su, D. L. Trees, P. A. RICE, P. Massari, C. A. Genco

This study compares N. gonorrhoeae gene expression in men and women with gonococcal infections, finding sex-specific differences in antibiotic resistance gene expression.

bioRxiv · May 11, 2018Microbiology

A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity

S. Ram, S. Gulati, L. A. Lewis, S. Chakraborti, B. Zheng, R. B. DeOliveira, G. W. Reed, A. D. Cox, J. Li, F. St. Michael, J. Stupak, X.-H. Su, S. Saha, C. S. Landig, A. Varki, P. A. RICE

This paper identifies a novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide that links HepII lactose expression with pathogenicity and vaccine potential.

bioRxiv · Apr 17, 2018Microbiology