A. Garcia-Sastre

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

This paper demonstrates that a novel TLR7/8 agonist adjuvant enables single-shot protection against SARS-CoV-2 and influenza in mice using recombinant spike protein and inactivated vaccines.

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

This study shows that deleting the polybasic cleavage site and introducing proline mutations in the SARS-CoV-2 spike protein enhances vaccine efficacy in a mouse model.

This study investigates SARS-CoV-2 infection, disease progression, and transmission in domestic cats through experimental challenge and monitoring.

This paper evaluates an inactivated Newcastle disease virus expressing the SARS-CoV-2 spike protein as a cost-effective vaccine, showing immunogenicity and protective efficacy in animal models.

This paper describes NDV vector vaccines expressing SARS-CoV-2 spike protein that protect mice from viral challenge and can be produced cost-effectively in chicken eggs.

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

This study shows that phenotypes in SARM1-deficient mice may be due to genetic differences between B6 and 129 backgrounds rather than SARM1 itself.

This study compares two SARS-CoV-2 infection models in mice: K18-hACE2 transgenic and adenovirus-mediated hACE2 delivery, showing differences in viral replication and disease outcomes.

This study identifies OTUB1 as a regulator of RIG-I immune signaling, showing it is degraded by influenza NS1 to suppress antiviral responses.

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.

The paper identifies early antiviral gene expression patterns and shows that RLRs drive stochastic IFNB1 expression independent of IFN.