A. L. Gloyn

Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein

This study uses CRISPR/Cas9 RNP to edit regulatory DNA elements in human islet cells, revealing their role in diabetes risk and β cell function.

Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.

This paper uses electrophysiological tools to functionally characterize iPSC-derived human β-like cells and assess the impact of a SLC30A8 variant on β-cell electrical coupling.

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.