P. J. Utz

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells

This study shows that STING V154M mutation in non-hematopoietic cells activates autoreactive lymphocytes, leading to autoantibodies and lung inflammation in mice, mirroring SAVI in humans.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Crosstalk of Histone Modifications in the Healthy Human Immune System

The paper analyzes histone post-translational modifications in human immune cells to uncover their interactions and functional implications.

A Unified Molecular Signature of Systemic Lupus Erythematosus Revealed by Integrated, Multi-Cohort Transcriptomic Analysis

This study identifies a 93-gene signature associated with SLE through multi-cohort transcriptomic analysis, showing its clinical relevance and independence from known SLE-related signatures.

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.