Y. Kuang

Global stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma

This paper develops a tumor-immune model for glioblastoma, identifies key parameters for treatment, and suggests combining immune checkpoint inhibitors with MDSC-targeting therapies.

Rescue of aged muscle stem cell quiescence defects by AKT inhibition revealed with a 3D biomimetic culture assay

This paper develops a 3D biomimetic culture assay to study muscle stem cell quiescence and shows that AKT inhibition rescues quiescence defects in aged cells.

IgD+ Age-Associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

The paper identifies IgD+CD21-CD23- age-associated B cells as precursors of infection-induced B cells in aged mice, which provide protective antibody responses and can be induced by inactivated vaccines.

Novel neutrophil subsets associated with sepsis, vascular dysfunction and metabolic alterations identified using systems immunology

The paper identifies novel neutrophil subsets in sepsis patients using systems immunology and links them to cytokines, metabolites, and lipids, enabling a predictive model for patient classification.

The sowing date changed the temperature and light conditions in the field modified the cadmium content of brown rice (Oryza sativa L.) by regulating the expression of Cd-related genes

This study shows that sowing date affects temperature and light conditions during rice growth, which in turn modifies cadmium content in brown rice by regulating Cd-related gene expression.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

A nondegenerate convective-reaction-density-dependent diffusion model of in vitro glioblastoma tumor growth

The paper develops a mathematical model for in vitro glioblastoma growth using density-dependent diffusion and validates it against experimental data.

Germline-encoded TCR-MHC contacts promote TCR V gene bias in umbilical cord blood T cell repertoire

The paper uses QTL mapping to show MHC variants bias TRBV gene usage in UCB samples, revealing germline-encoded TCR-MHC contacts influence TCR repertoire.