A. Munoz

SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells.

This study shows that vitamin D inhibits the Wnt/β-catenin pathway in colon cancer cells by activating SIRT1, which deacetylates and excludes β-catenin from the nucleus, reducing tumor growth.

Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer

This study shows vitamin D activates SIRT1 via K610 deacetylation in colon cancer, linking it to antiproliferative effects and suggesting therapeutic potential for VD-deficient patients.

Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

This study shows dexamethasone enhances CAR T cell persistence and function by upregulating IL7R, improving anti-tumor efficacy in vivo.

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

This study identifies X chromosome dosage and DHA reduction as drivers of statin-induced dysglycemia and mitochondrial dysfunction in females.

Waning and boosting of functional humoral immunity to SARS-CoV-2

This study compares the waning and boosting of functional humoral immunity induced by CoronaVac and BNT162b2 vaccines, showing differences in kinetics and boosting efficacy.

Chemotherapy induces a YAP1-dependent fetal conversion to human Colorectal Cancer cells that is predictive of poor patient outcome

The paper shows that sublethal chemotherapy induces a YAP1-dependent fetal phenotype in colorectal cancer cells, which predicts poor patient outcomes.