Y. Ishii

Endocytosis suppresses stochastic collapse in fibroblast-macrophage circuits under shared resource competition

The paper models fibroblast-macrophage circuits to show endocytosis stabilizes coexistence under resource competition by suppressing stochastic failure, with macrophage CSF uptake being critical.

Experimental evolution for the recovery of growth loss due to genome reduction

This study shows that genome reduction in E. coli can be compensated by experimental evolution, leading to recovery of growth fitness through diverse mutations and transcriptome reorganization.

Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction

This study identifies remdesivir as a selective agonist of the urotensin-II receptor, linking its cardiotoxicity to receptor activation and genetic variants.

Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

The paper shows that low pH triggers cellulase-mediated release of monosaccharides from algal cell walls in coral symbionts.

Single mutation makes Escherichia coli an insect mutualist

The paper shows that a single mutation in E. coli enables it to become an insect mutualist by disrupting carbon catabolite repression.

Photocatalyst under visible light irradiation inactivates SARS-CoV-2 on an abiotic surface

This study shows that a visible light-responsive photocatalyst inactivates SARS-CoV-2 on surfaces under specific conditions, reducing viral titers and spike protein levels.

BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma

This study shows BAP1 and YY1 suppress TRAIL receptor expression in MPM, making them potential targets to enhance TRAIL therapy.

Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1

This study identifies BACH1 as a regulator of ferroptosis by modulating glutathione and iron metabolism, showing its role in myocardial infarction resistance.