A. Philp

Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators

This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.

Establishment and characterisation of primary skeletal muscle cell cultures from patients with advanced Chronic Kidney Disease

This study establishes primary skeletal muscle cell cultures from NDD-CKD patients and healthy controls, finding increased mRNA expression of myogenic markers and protein degradation markers in CKD cultures.

Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis

This study examines the relationship between vitamin D deficiency and exercise capacity in CKD patients, finding no strong link to muscle size but a possible role in reduced exercise capacity.

Nicotinamide Riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise

This study investigates whether NR supplementation affects metabolic responses to endurance exercise in human skeletal muscle, finding no significant changes in key metabolic markers or mitochondrial adaptation.

Diet-Induced Vitamin D Deficiency Results in Reduced Skeletal Muscle Mitochondrial Respiration in C57BL/6J Mice

Protein-carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle

This study shows that protein-carbohydrate ingestion in human skeletal muscle increases Vps34 translocation to the cell periphery and its co-localization with mTOR, without altering Vps34 kinase activity or preventing mTORC1 activation.

The Vitamin D Receptor (VDR) Regulates Mitochondrial Function in C2C12 Myoblasts

This study shows that VDR knockdown in C2C12 myoblasts reduces mitochondrial respiration and ATP production, suggesting VDR regulates skeletal muscle mitochondrial function.

Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese.

This study shows that exercising before nutrient intake increases lipid utilization and improves insulin sensitivity in overweight or obese men over 6 weeks.